Cargando…

Simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on PVP-graphene composite

A method with high sensitivity, good accuracy and fast response is of ever increasing importance for the simultaneous detection of AA, DA and UA. In this paper, a simple and sensitive electrochemical sensor, which based on the polyvinylpyrrolidone (PVP)-graphene composite film modified glassy carbon...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Yiyong, Deng, Peihong, Tian, Yaling, Feng, Jinxia, Xiao, Jingyun, Li, Junhua, Liu, Jun, Li, Guangli, He, Quanguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419206/
https://www.ncbi.nlm.nih.gov/pubmed/32778119
http://dx.doi.org/10.1186/s12951-020-00672-9
_version_ 1783569833845063680
author Wu, Yiyong
Deng, Peihong
Tian, Yaling
Feng, Jinxia
Xiao, Jingyun
Li, Junhua
Liu, Jun
Li, Guangli
He, Quanguo
author_facet Wu, Yiyong
Deng, Peihong
Tian, Yaling
Feng, Jinxia
Xiao, Jingyun
Li, Junhua
Liu, Jun
Li, Guangli
He, Quanguo
author_sort Wu, Yiyong
collection PubMed
description A method with high sensitivity, good accuracy and fast response is of ever increasing importance for the simultaneous detection of AA, DA and UA. In this paper, a simple and sensitive electrochemical sensor, which based on the polyvinylpyrrolidone (PVP)-graphene composite film modified glassy carbon electrode (PVP-GR/GCE), was presented for detecting ascorbic acid (AA), dopamine (DA) and uric acid (UA) simultaneously. The PVP-GR/GCE has excellent electrocatalytic activity for the oxidation of AA, DA and UA. The second-order derivative linear sweep voltammetry was used for the electrochemical measurements. The peak potential differences of DA-AA, DA-UA, and UA-AA (measured on the PVP-GR/GCE) were 212, 130 and 342 mV respectively. Besides, the over potential of AA, DA and UA reduced obviously, so did the peak current increase. Under the optimum conditions, the linear ranges of AA, DA and UA were 4.0 μM–1.0 mM, 0.02–100 μM, and 0.04–100 μM, respectively. The detection limits were 0.8 μM, 0.002 μM and 0.02 μM for AA, DA, and UA. The electrochemical sensor presented the advantages of high sensitivity and selectivity, excellent reproducibility and long-term stability. Furthermore, the sensor was successfully applied to the analysis of real samples. [Image: see text]
format Online
Article
Text
id pubmed-7419206
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-74192062020-08-12 Simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on PVP-graphene composite Wu, Yiyong Deng, Peihong Tian, Yaling Feng, Jinxia Xiao, Jingyun Li, Junhua Liu, Jun Li, Guangli He, Quanguo J Nanobiotechnology Research A method with high sensitivity, good accuracy and fast response is of ever increasing importance for the simultaneous detection of AA, DA and UA. In this paper, a simple and sensitive electrochemical sensor, which based on the polyvinylpyrrolidone (PVP)-graphene composite film modified glassy carbon electrode (PVP-GR/GCE), was presented for detecting ascorbic acid (AA), dopamine (DA) and uric acid (UA) simultaneously. The PVP-GR/GCE has excellent electrocatalytic activity for the oxidation of AA, DA and UA. The second-order derivative linear sweep voltammetry was used for the electrochemical measurements. The peak potential differences of DA-AA, DA-UA, and UA-AA (measured on the PVP-GR/GCE) were 212, 130 and 342 mV respectively. Besides, the over potential of AA, DA and UA reduced obviously, so did the peak current increase. Under the optimum conditions, the linear ranges of AA, DA and UA were 4.0 μM–1.0 mM, 0.02–100 μM, and 0.04–100 μM, respectively. The detection limits were 0.8 μM, 0.002 μM and 0.02 μM for AA, DA, and UA. The electrochemical sensor presented the advantages of high sensitivity and selectivity, excellent reproducibility and long-term stability. Furthermore, the sensor was successfully applied to the analysis of real samples. [Image: see text] BioMed Central 2020-08-10 /pmc/articles/PMC7419206/ /pubmed/32778119 http://dx.doi.org/10.1186/s12951-020-00672-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wu, Yiyong
Deng, Peihong
Tian, Yaling
Feng, Jinxia
Xiao, Jingyun
Li, Junhua
Liu, Jun
Li, Guangli
He, Quanguo
Simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on PVP-graphene composite
title Simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on PVP-graphene composite
title_full Simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on PVP-graphene composite
title_fullStr Simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on PVP-graphene composite
title_full_unstemmed Simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on PVP-graphene composite
title_short Simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on PVP-graphene composite
title_sort simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on pvp-graphene composite
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419206/
https://www.ncbi.nlm.nih.gov/pubmed/32778119
http://dx.doi.org/10.1186/s12951-020-00672-9
work_keys_str_mv AT wuyiyong simultaneousandsensitivedeterminationofascorbicaciddopamineanduricacidviaanelectrochemicalsensorbasedonpvpgraphenecomposite
AT dengpeihong simultaneousandsensitivedeterminationofascorbicaciddopamineanduricacidviaanelectrochemicalsensorbasedonpvpgraphenecomposite
AT tianyaling simultaneousandsensitivedeterminationofascorbicaciddopamineanduricacidviaanelectrochemicalsensorbasedonpvpgraphenecomposite
AT fengjinxia simultaneousandsensitivedeterminationofascorbicaciddopamineanduricacidviaanelectrochemicalsensorbasedonpvpgraphenecomposite
AT xiaojingyun simultaneousandsensitivedeterminationofascorbicaciddopamineanduricacidviaanelectrochemicalsensorbasedonpvpgraphenecomposite
AT lijunhua simultaneousandsensitivedeterminationofascorbicaciddopamineanduricacidviaanelectrochemicalsensorbasedonpvpgraphenecomposite
AT liujun simultaneousandsensitivedeterminationofascorbicaciddopamineanduricacidviaanelectrochemicalsensorbasedonpvpgraphenecomposite
AT liguangli simultaneousandsensitivedeterminationofascorbicaciddopamineanduricacidviaanelectrochemicalsensorbasedonpvpgraphenecomposite
AT hequanguo simultaneousandsensitivedeterminationofascorbicaciddopamineanduricacidviaanelectrochemicalsensorbasedonpvpgraphenecomposite