Combined Intravenous Sildenafil and l-Arginine Administration in a Porcine Animal Model: Hemodynamic Safety Profile and Effects on Coronary Blood Flow

BACKGROUND: Endothelial dysfunction in the nitric oxide-cyclic guanosine monophosphate pathway is a potential contributor to perioperative myocardial ischemia. The nitric oxide precursor, l-arginine, and the cyclic guanosine monophosphate degradation blocker, sildenafil, have vasodilatory effects un...

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Detalles Bibliográficos
Autores principales: Brzezinski, Marek, Dincheva, Gabriela R., Alloo, Kelsey, Wong, Celeste, Feng, Chun-Miao, Tom, Wynnis L., Salahieh, Ali, Wallace, Arthur W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419398/
https://www.ncbi.nlm.nih.gov/pubmed/32720006
http://dx.doi.org/10.1007/s40268-020-00318-z

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