Cargando…

Transcriptional mutagenesis dramatically alters genome-wide p53 transactivation landscape

The transcriptional error rate can be significantly increased by the presence of DNA lesions that instruct mis-insertion during transcription; a process referred to as transcriptional mutagenesis (TM) that can result in altered protein function. Herein, we determined the effect of O(6)-methylguanine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Shuo, Ezerskyte, Monika, Wang, Jingwen, Pelechano, Vicent, Dreij, Kristian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419513/ https://www.ncbi.nlm.nih.gov/pubmed/32782319 http://dx.doi.org/10.1038/s41598-020-70412-4

Ejemplares similares

Transcriptional mutagenesis reduces splicing fidelity in mammalian cells
por: Paredes, João A., et al.
Publicado: (2017)

O(6)-methylguanine–induced transcriptional mutagenesis reduces p53 tumor-suppressor function
por: Ezerskyte, Monika, et al.
Publicado: (2018)

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells
por: Menendez, Daniel, et al.
Publicado: (2013)

Regression based predictor for p53 transactivation
por: Gowrisankar, Sivakumar, et al.
Publicado: (2009)

Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction
por: Thayer, Kelly M., et al.
Publicado: (2016)

O(6)-Methylguanine induces altered proteins at the level of transcription in human cells
por: Burns, John A., et al.
Publicado: (2010)

Transcript isoform sequencing reveals widespread promoter-proximal transcriptional termination in Arabidopsis
por: Thomas, Quentin Angelo, et al.
Publicado: (2020)

Wide-line NMR and DSC studies on intrinsically disordered p53 transactivation domain and its helically pre-structured segment
por: Tompa, Peter, et al.
Publicado: (2016)

A dramatic decline in fruit citrate induced by mutagenesis of a NAC transcription factor, AcNAC1
por: Fu, Bei‐ling, et al.
Publicado: (2023)

Activation of Caspases in p53‐induced Transactivation‐independent Apoptosis
por: Gao, Chongfeng, et al.
Publicado: (1999)

Extensive transcriptional heterogeneity revealed by isoform profiling
por: Pelechano, Vicent, et al.
Publicado: (2013)

p32 is a negative regulator of p53 tetramerization and transactivation
por: Ghate, Nikhil Baban, et al.
Publicado: (2019)

The Transcriptional Landscape of p53 Signalling Pathway
por: Tanikawa, Chizu, et al.
Publicado: (2017)

Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation
por: Tatavosian, Roubina, et al.
Publicado: (2023)

Direct α-synuclein promoter transactivation by the tumor suppressor p53
por: Duplan, Eric, et al.
Publicado: (2016)

Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53
por: Miyamoto, Takafumi, et al.
Publicado: (2017)

OPUSeq simplifies detection of low-frequency DNA variants and uncovers fragmentase-associated artifacts
por: Alekseenko, Alisa, et al.
Publicado: (2022)

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters
por: Loughery, Jayne, et al.
Publicado: (2014)

Transactivation by low and high levels of human p53 reveals new physical rules of engagement and novel super-transactivation sequences
por: Menendez, Daniel, et al.
Publicado: (2012)

A Complete Set of Nascent Transcription Rates for Yeast Genes
por: Pelechano, Vicent, et al.
Publicado: (2010)

Human p53‐p51 (p53‐Related) Fusion Protein: A Potent BAX Transactivator
por: Ikawa, Shuntaro, et al.
Publicado: (1999)

DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism
por: Chen, Ling, et al.
Publicado: (2019)

The Influence of Quadruplex Structure in Proximity to P53 Target Sequences on the Transactivation Potential of P53 Alpha Isoforms
por: Porubiaková, Otília, et al.
Publicado: (2019)

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53
por: Jordan, Jennifer J., et al.
Publicado: (2008)

Differences in the transactivation domains of p53 family members: a computational study
por: Mavinahalli, Jagadeesh N, et al.
Publicado: (2010)

Whole-genome cartography of p53 response elements ranked on transactivation potential
por: Tebaldi, Toma, et al.
Publicado: (2015)

The 9aaTAD Transactivation Domains: From Gal4 to p53
por: Piskacek, Martin, et al.
Publicado: (2016)

High-throughput 5′P sequencing enables the study of degradation-associated ribosome stalls
por: Zhang, Yujie, et al.
Publicado: (2021)

Application of high-throughput 5′P sequencing for the study of co-translational mRNA decay
por: Zhang, Yujie, et al.
Publicado: (2021)

Gentian violet induces wtp53 transactivation in cancer cells
por: GARUFI, ALESSIA, et al.
Publicado: (2014)

Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53
por: Hafsi, Hind, et al.
Publicado: (2013)

D133P53, directly transactivated by p53, prevents p53-mediated apoptosis without inhibiting p53-mediated cell cycle arrest
por: Aoubala, M, et al.
Publicado: (2010)

Transcription-driven chromatin repression of Intragenic transcription start sites
por: Nielsen, Mathias, et al.
Publicado: (2019)

Correction: Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53
por: Jordan, Jennifer J., et al.
Publicado: (2008)

MEF/ELF4 transactivation by E2F1 is inhibited by p53
por: Taura, Manabu, et al.
Publicado: (2011)

Correction: Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53
por: Jordan, Jennifer J., et al.
Publicado: (2008)

Modulation of the Disordered Conformational Ensembles of the p53 Transactivation Domain by Cancer-Associated Mutations
por: Ganguly, Debabani, et al.
Publicado: (2015)

Modulation of p53 Transactivation Domain Conformations by Ligand Binding and Cancer-Associated Mutations
por: Liu, Xiaorong, et al.
Publicado: (2020)

p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR
por: Usluer, Sinem, et al.
Publicado: (2021)

Interaction between Transactivation Domain of p53 and Middle Part of TBP-Like Protein (TLP) Is Involved in TLP-Stimulated and p53-Activated Transcription from the p21 Upstream Promoter
por: Maeda, Ryo, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fqm3276irgpidubhtamj7cqjv1