Epigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H(3) receptor for Prader–Willi Syndrome

The role of epigenetic regulation is in large parts connected to cancer, but additionally, its therapeutic claim in neurological disorders has emerged. Inhibition of histone H3 lysine N-methyltransferase, especially G9a, has been recently shown to restore candidate genes from silenced parental chrom...

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Detalles Bibliográficos
Autores principales: Reiner, David, Seifert, Ludwig, Deck, Caroline, Schüle, Roland, Jung, Manfred, Stark, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419559/
https://www.ncbi.nlm.nih.gov/pubmed/32782417
http://dx.doi.org/10.1038/s41598-020-70523-y

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