Fecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice

The significance of the microbiota-gut-brain axis has been increasingly recognized as a major modulator of autoimmunity. Here, we aim to characterize the gut microbiota of a large cohort of treatment-naïve anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis patients relative to that of heal...

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Autores principales: Chen, Hao, Chen, Zhaoyu, Shen, Liping, Wu, Xiuhua, Ma, Xueying, Lin, Dengna, Zhang, Man, Ma, Xiaomeng, Liu, Yingying, Wang, Zhanhang, Zhang, Yuefeng, Kuang, Zuying, Lu, Zhiwei, Li, Xuefei, Ma, Lili, Lin, Xiuli, Si, Lei, Chen, Xiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419566/
https://www.ncbi.nlm.nih.gov/pubmed/32821439
http://dx.doi.org/10.1038/s41420-020-00309-8
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author Chen, Hao
Chen, Zhaoyu
Shen, Liping
Wu, Xiuhua
Ma, Xueying
Lin, Dengna
Zhang, Man
Ma, Xiaomeng
Liu, Yingying
Wang, Zhanhang
Zhang, Yuefeng
Kuang, Zuying
Lu, Zhiwei
Li, Xuefei
Ma, Lili
Lin, Xiuli
Si, Lei
Chen, Xiaohong
author_facet Chen, Hao
Chen, Zhaoyu
Shen, Liping
Wu, Xiuhua
Ma, Xueying
Lin, Dengna
Zhang, Man
Ma, Xiaomeng
Liu, Yingying
Wang, Zhanhang
Zhang, Yuefeng
Kuang, Zuying
Lu, Zhiwei
Li, Xuefei
Ma, Lili
Lin, Xiuli
Si, Lei
Chen, Xiaohong
author_sort Chen, Hao
collection PubMed
description The significance of the microbiota-gut-brain axis has been increasingly recognized as a major modulator of autoimmunity. Here, we aim to characterize the gut microbiota of a large cohort of treatment-naïve anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis patients relative to that of healthy controls (HCs). Relative to HCs, anti-NMDAR encephalitis patients had a decreased microbiome alpha-diversity index, marked disturbances of gut microbial composition and intestinal permeability damage. Disturbed microbiota in anti-NMDAR encephalitis patients might be linked with different clinical characteristics. Imputed KEGG analysis revealed perturbations of functional modules in the gut microbiomes of anti-NMDAR encephalitis. Compared to HCs, microbiota-depleted mice receiving fecal microbiota transplantation (FMT) from anti-NMDAR encephalitis patients had hypersensitivity and cognitive impairment. Furthermore, anti-NMDAR encephalitis FMT mice showed altered T cells in the spleen and small intestine lamina propria with an increased Th17 cells. Overall, this study first suggests that the anti-NMDAR encephalitis microbiome itself can influence neurologic, Th17 response and behavioral function. The gut microbiota is a potential therapeutic target for anti-NMDAR encephalitis.
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spelling pubmed-74195662020-08-18 Fecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice Chen, Hao Chen, Zhaoyu Shen, Liping Wu, Xiuhua Ma, Xueying Lin, Dengna Zhang, Man Ma, Xiaomeng Liu, Yingying Wang, Zhanhang Zhang, Yuefeng Kuang, Zuying Lu, Zhiwei Li, Xuefei Ma, Lili Lin, Xiuli Si, Lei Chen, Xiaohong Cell Death Discov Article The significance of the microbiota-gut-brain axis has been increasingly recognized as a major modulator of autoimmunity. Here, we aim to characterize the gut microbiota of a large cohort of treatment-naïve anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis patients relative to that of healthy controls (HCs). Relative to HCs, anti-NMDAR encephalitis patients had a decreased microbiome alpha-diversity index, marked disturbances of gut microbial composition and intestinal permeability damage. Disturbed microbiota in anti-NMDAR encephalitis patients might be linked with different clinical characteristics. Imputed KEGG analysis revealed perturbations of functional modules in the gut microbiomes of anti-NMDAR encephalitis. Compared to HCs, microbiota-depleted mice receiving fecal microbiota transplantation (FMT) from anti-NMDAR encephalitis patients had hypersensitivity and cognitive impairment. Furthermore, anti-NMDAR encephalitis FMT mice showed altered T cells in the spleen and small intestine lamina propria with an increased Th17 cells. Overall, this study first suggests that the anti-NMDAR encephalitis microbiome itself can influence neurologic, Th17 response and behavioral function. The gut microbiota is a potential therapeutic target for anti-NMDAR encephalitis. Nature Publishing Group UK 2020-08-11 /pmc/articles/PMC7419566/ /pubmed/32821439 http://dx.doi.org/10.1038/s41420-020-00309-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Hao
Chen, Zhaoyu
Shen, Liping
Wu, Xiuhua
Ma, Xueying
Lin, Dengna
Zhang, Man
Ma, Xiaomeng
Liu, Yingying
Wang, Zhanhang
Zhang, Yuefeng
Kuang, Zuying
Lu, Zhiwei
Li, Xuefei
Ma, Lili
Lin, Xiuli
Si, Lei
Chen, Xiaohong
Fecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice
title Fecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice
title_full Fecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice
title_fullStr Fecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice
title_full_unstemmed Fecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice
title_short Fecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice
title_sort fecal microbiota transplantation from patients with autoimmune encephalitis modulates th17 response and relevant behaviors in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419566/
https://www.ncbi.nlm.nih.gov/pubmed/32821439
http://dx.doi.org/10.1038/s41420-020-00309-8
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