Inhibition of the SET8 Pathway Ameliorates Lung Fibrosis Even Through Fibroblast Dedifferentiation

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown etiopathogenesis. The activation of extracellular matrix (ECM)-producing myofibroblasts plays a key role in fibrotic tissue remodeling. The dedifferentiation of myofibroblasts has attracted considerable attention as a promising t...

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Detalles Bibliográficos
Autores principales: Ugai, Keita, Matsuda, Shuichi, Mikami, Hideki, Shimada, Ayako, Misawa, Tomoko, Nakamura, Hiroyuki, Tatsumi, Koichiro, Hatano, Masahiko, Murayama, Toshihiko, Kasuya, Yoshitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419601/
https://www.ncbi.nlm.nih.gov/pubmed/32850975
http://dx.doi.org/10.3389/fmolb.2020.00192

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