Intestinal Stem Cell Niche Defects Result in Impaired 3D Organoid Formation in Mouse Models of Crohn's Disease-like Ileitis

Intestinal epithelial barrier dysfunction is a risk factor in the pathogenesis of Crohn’s disease (CD); however, no corrective FDA-approved therapies exist. We used an enteroid (EnO)-based system in two murine models of experimental CD, SAMP1/YitFc (SAMP) and TNF(ΔARE/+) (TNF). While severely inflam...

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Detalles Bibliográficos
Autores principales: Buttó, Ludovica F., Pelletier, Adam, More, Shyam K., Zhao, Nan, Osme, Abdullah, Hager, Christopher L., Ghannoum, Mahmoud A., Sekaly, Rafick-Pierre, Cominelli, Fabio, Dave, Maneesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419719/
https://www.ncbi.nlm.nih.gov/pubmed/32679063
http://dx.doi.org/10.1016/j.stemcr.2020.06.017

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