A Single Radioprotective Dose of Prostaglandin E(2) Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells

Ionizing radiation exposure results in acute and delayed bone marrow suppression. Treatment of mice with 16,16-dimethyl prostaglandin E(2) (dmPGE(2)) prior to lethal ionizing radiation (IR) facilitates survival, but the cellular and molecular mechanisms are unclear. In this study we show that dmPGE(...

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Detalles Bibliográficos
Autores principales: Patterson, Andrea M., Liu, Liqiong, Sampson, Carol H., Plett, P. Artur, Li, Hongge, Singh, Pratibha, Mohammad, Khalid S., Hoggatt, Jonathan, Capitano, Maegan L., Orschell, Christie M., Pelus, Louis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419738/
https://www.ncbi.nlm.nih.gov/pubmed/32735825
http://dx.doi.org/10.1016/j.stemcr.2020.07.004

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