Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

The systemic amyloidoses are diverse disorders in which misfolded proteins are secreted by effector organs and deposited as proteotoxic aggregates at downstream tissues. Although well described clinically, the contribution of synthesizing organs to amyloid disease pathogenesis is unknown. Here, we u...

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Detalles Bibliográficos
Autores principales: Giadone, Richard M., Liberti, Derek C., Matte, Taylor M., Rosarda, Jessica D., Torres-Arancivia, Celia, Ghosh, Sabrina, Diedrich, Jolene K., Pankow, Sandra, Skvir, Nicholas, Jean, J.C., Yates, John R., Wilson, Andrew A., Connors, Lawreen H., Kotton, Darrell N., Wiseman, R. Luke, Murphy, George J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419739/
https://www.ncbi.nlm.nih.gov/pubmed/32735824
http://dx.doi.org/10.1016/j.stemcr.2020.07.003

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