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NPC1 deficiency impairs cerebellar postnatal development of microglia and climbing fiber refinement in a mouse model of Niemann–Pick disease type C

Little is known about the effects of NPC1 deficiency in brain development and whether these effects contribute to neurodegeneration in Niemann–Pick disease type C (NPC). Degeneration of cerebellar Purkinje cells occurs at an earlier stage and to a greater extent in NPC; therefore, we analyzed the ef...

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Detalles Bibliográficos
Autores principales:	Boyle, Bridget R., Melli, Sierra E., Altreche, Ruth S., Padron, Zachary M., Yousufzai, Fawad A. K., Kim, Sarah, Vasquez, Mariella D., Carone, Dawn M., Carone, Benjamin R., Soto, Ileana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7420841/ https://www.ncbi.nlm.nih.gov/pubmed/32611604 http://dx.doi.org/10.1242/dev.189019

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