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The genetic architecture of human brainstem structures and their involvement in common brain disorders
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first link...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7421944/ https://www.ncbi.nlm.nih.gov/pubmed/32782260 http://dx.doi.org/10.1038/s41467-020-17376-1 |
| _version_ | 1783569996981469184 |
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| author | Elvsåshagen, Torbjørn Bahrami, Shahram van der Meer, Dennis Agartz, Ingrid Alnæs, Dag Barch, Deanna M. Baur-Streubel, Ramona Bertolino, Alessandro Beyer, Mona K. Blasi, Giuseppe Borgwardt, Stefan Boye, Birgitte Buitelaar, Jan Bøen, Erlend Celius, Elisabeth Gulowsen Cervenka, Simon Conzelmann, Annette Coynel, David Di Carlo, Pasquale Djurovic, Srdjan Eisenacher, Sarah Espeseth, Thomas Fatouros-Bergman, Helena Flyckt, Lena Franke, Barbara Frei, Oleksandr Gelao, Barbara Harbo, Hanne Flinstad Hartman, Catharina A. Håberg, Asta Heslenfeld, Dirk Hoekstra, Pieter J. Høgestøl, Einar A. Jonassen, Rune Jönsson, Erik G. Kirsch, Peter Kłoszewska, Iwona Lagerberg, Trine Vik Landrø, Nils Inge Le Hellard, Stephanie Lesch, Klaus-Peter Maglanoc, Luigi A. Malt, Ulrik F. Mecocci, Patrizia Melle, Ingrid Meyer-Lindenberg, Andreas Moberget, Torgeir Nordvik, Jan Egil Nyberg, Lars Connell, Kevin S. O’ Oosterlaan, Jaap Papalino, Marco Papassotiropoulos, Andreas Pauli, Paul Pergola, Giulio Persson, Karin de Quervain, Dominique Reif, Andreas Rokicki, Jaroslav van Rooij, Daan Shadrin, Alexey A. Schmidt, André Schwarz, Emanuel Selbæk, Geir Soininen, Hilkka Sowa, Piotr Steen, Vidar M. Tsolaki, Magda Vellas, Bruno Wang, Lei Westman, Eric Ziegler, Georg C. Zink, Mathias Andreassen, Ole A. Westlye, Lars T. Kaufmann, Tobias |
| author_facet | Elvsåshagen, Torbjørn Bahrami, Shahram van der Meer, Dennis Agartz, Ingrid Alnæs, Dag Barch, Deanna M. Baur-Streubel, Ramona Bertolino, Alessandro Beyer, Mona K. Blasi, Giuseppe Borgwardt, Stefan Boye, Birgitte Buitelaar, Jan Bøen, Erlend Celius, Elisabeth Gulowsen Cervenka, Simon Conzelmann, Annette Coynel, David Di Carlo, Pasquale Djurovic, Srdjan Eisenacher, Sarah Espeseth, Thomas Fatouros-Bergman, Helena Flyckt, Lena Franke, Barbara Frei, Oleksandr Gelao, Barbara Harbo, Hanne Flinstad Hartman, Catharina A. Håberg, Asta Heslenfeld, Dirk Hoekstra, Pieter J. Høgestøl, Einar A. Jonassen, Rune Jönsson, Erik G. Kirsch, Peter Kłoszewska, Iwona Lagerberg, Trine Vik Landrø, Nils Inge Le Hellard, Stephanie Lesch, Klaus-Peter Maglanoc, Luigi A. Malt, Ulrik F. Mecocci, Patrizia Melle, Ingrid Meyer-Lindenberg, Andreas Moberget, Torgeir Nordvik, Jan Egil Nyberg, Lars Connell, Kevin S. O’ Oosterlaan, Jaap Papalino, Marco Papassotiropoulos, Andreas Pauli, Paul Pergola, Giulio Persson, Karin de Quervain, Dominique Reif, Andreas Rokicki, Jaroslav van Rooij, Daan Shadrin, Alexey A. Schmidt, André Schwarz, Emanuel Selbæk, Geir Soininen, Hilkka Sowa, Piotr Steen, Vidar M. Tsolaki, Magda Vellas, Bruno Wang, Lei Westman, Eric Ziegler, Georg C. Zink, Mathias Andreassen, Ole A. Westlye, Lars T. Kaufmann, Tobias |
| author_sort | Elvsåshagen, Torbjørn |
| collection | PubMed |
| description | Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders. |
| format | Online Article Text |
| id | pubmed-7421944 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-74219442020-08-18 The genetic architecture of human brainstem structures and their involvement in common brain disorders Elvsåshagen, Torbjørn Bahrami, Shahram van der Meer, Dennis Agartz, Ingrid Alnæs, Dag Barch, Deanna M. Baur-Streubel, Ramona Bertolino, Alessandro Beyer, Mona K. Blasi, Giuseppe Borgwardt, Stefan Boye, Birgitte Buitelaar, Jan Bøen, Erlend Celius, Elisabeth Gulowsen Cervenka, Simon Conzelmann, Annette Coynel, David Di Carlo, Pasquale Djurovic, Srdjan Eisenacher, Sarah Espeseth, Thomas Fatouros-Bergman, Helena Flyckt, Lena Franke, Barbara Frei, Oleksandr Gelao, Barbara Harbo, Hanne Flinstad Hartman, Catharina A. Håberg, Asta Heslenfeld, Dirk Hoekstra, Pieter J. Høgestøl, Einar A. Jonassen, Rune Jönsson, Erik G. Kirsch, Peter Kłoszewska, Iwona Lagerberg, Trine Vik Landrø, Nils Inge Le Hellard, Stephanie Lesch, Klaus-Peter Maglanoc, Luigi A. Malt, Ulrik F. Mecocci, Patrizia Melle, Ingrid Meyer-Lindenberg, Andreas Moberget, Torgeir Nordvik, Jan Egil Nyberg, Lars Connell, Kevin S. O’ Oosterlaan, Jaap Papalino, Marco Papassotiropoulos, Andreas Pauli, Paul Pergola, Giulio Persson, Karin de Quervain, Dominique Reif, Andreas Rokicki, Jaroslav van Rooij, Daan Shadrin, Alexey A. Schmidt, André Schwarz, Emanuel Selbæk, Geir Soininen, Hilkka Sowa, Piotr Steen, Vidar M. Tsolaki, Magda Vellas, Bruno Wang, Lei Westman, Eric Ziegler, Georg C. Zink, Mathias Andreassen, Ole A. Westlye, Lars T. Kaufmann, Tobias Nat Commun Article Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders. Nature Publishing Group UK 2020-08-11 /pmc/articles/PMC7421944/ /pubmed/32782260 http://dx.doi.org/10.1038/s41467-020-17376-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Elvsåshagen, Torbjørn Bahrami, Shahram van der Meer, Dennis Agartz, Ingrid Alnæs, Dag Barch, Deanna M. Baur-Streubel, Ramona Bertolino, Alessandro Beyer, Mona K. Blasi, Giuseppe Borgwardt, Stefan Boye, Birgitte Buitelaar, Jan Bøen, Erlend Celius, Elisabeth Gulowsen Cervenka, Simon Conzelmann, Annette Coynel, David Di Carlo, Pasquale Djurovic, Srdjan Eisenacher, Sarah Espeseth, Thomas Fatouros-Bergman, Helena Flyckt, Lena Franke, Barbara Frei, Oleksandr Gelao, Barbara Harbo, Hanne Flinstad Hartman, Catharina A. Håberg, Asta Heslenfeld, Dirk Hoekstra, Pieter J. Høgestøl, Einar A. Jonassen, Rune Jönsson, Erik G. Kirsch, Peter Kłoszewska, Iwona Lagerberg, Trine Vik Landrø, Nils Inge Le Hellard, Stephanie Lesch, Klaus-Peter Maglanoc, Luigi A. Malt, Ulrik F. Mecocci, Patrizia Melle, Ingrid Meyer-Lindenberg, Andreas Moberget, Torgeir Nordvik, Jan Egil Nyberg, Lars Connell, Kevin S. O’ Oosterlaan, Jaap Papalino, Marco Papassotiropoulos, Andreas Pauli, Paul Pergola, Giulio Persson, Karin de Quervain, Dominique Reif, Andreas Rokicki, Jaroslav van Rooij, Daan Shadrin, Alexey A. Schmidt, André Schwarz, Emanuel Selbæk, Geir Soininen, Hilkka Sowa, Piotr Steen, Vidar M. Tsolaki, Magda Vellas, Bruno Wang, Lei Westman, Eric Ziegler, Georg C. Zink, Mathias Andreassen, Ole A. Westlye, Lars T. Kaufmann, Tobias The genetic architecture of human brainstem structures and their involvement in common brain disorders |
| title | The genetic architecture of human brainstem structures and their involvement in common brain disorders |
| title_full | The genetic architecture of human brainstem structures and their involvement in common brain disorders |
| title_fullStr | The genetic architecture of human brainstem structures and their involvement in common brain disorders |
| title_full_unstemmed | The genetic architecture of human brainstem structures and their involvement in common brain disorders |
| title_short | The genetic architecture of human brainstem structures and their involvement in common brain disorders |
| title_sort | genetic architecture of human brainstem structures and their involvement in common brain disorders |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7421944/ https://www.ncbi.nlm.nih.gov/pubmed/32782260 http://dx.doi.org/10.1038/s41467-020-17376-1 |
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