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Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. Current insights and future directions
New insights into the complex and fine-regulated inflammatory mechanisms involved in the endometrium reveal multiple facets to the problem of endometrial inflammation. However, the entity termed chronic endometritis is to date restricted to infectious etiology and managed with antibiotics. Conversel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422289/ https://www.ncbi.nlm.nih.gov/pubmed/32802019 http://dx.doi.org/10.5114/pm.2020.97863 |
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author | Drizi, Amal Djokovic, Dusan Laganà, Antonio Simone van Herendael, Bruno |
author_facet | Drizi, Amal Djokovic, Dusan Laganà, Antonio Simone van Herendael, Bruno |
author_sort | Drizi, Amal |
collection | PubMed |
description | New insights into the complex and fine-regulated inflammatory mechanisms involved in the endometrium reveal multiple facets to the problem of endometrial inflammation. However, the entity termed chronic endometritis is to date restricted to infectious etiology and managed with antibiotics. Conversely, the concept of impaired inflammatory state of the endometrium (IISE) provides a more global approach to defective endometrial inflammation, considering both infectious and non-infectious etiology. A non-systematic review was done through a search on MEDLINE, EMBASE, Global Health, The Cochrane Library, Health Technology Assessment Database and Web of Science, research registers. Pertinent original and review articles, published in English or French until December 31, 2019, were selected. A compelling body of evidence demonstrates transient, repeated and persistent IISE to be a major factor of most problematic disorders in obstetrics/gynecology, such as endometrial polyps, unexplained infertility, miscarriage, placenta-related pathology and endometrial cancer. When scheduled accordingly, hysteroscopy can play a key role in the IISE assessment. Robust data suggests the pertinence of minimal-effective anti-inflammatory regimens for therapeutic IISE targeting. This review provides a comprehensive update on the multiple facets of inflammation in the endometrial physiology and pathology. Further research is needed to improve classification, diagnosis and treatment of IISE. |
format | Online Article Text |
id | pubmed-7422289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-74222892020-08-14 Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. Current insights and future directions Drizi, Amal Djokovic, Dusan Laganà, Antonio Simone van Herendael, Bruno Prz Menopauzalny Review Paper New insights into the complex and fine-regulated inflammatory mechanisms involved in the endometrium reveal multiple facets to the problem of endometrial inflammation. However, the entity termed chronic endometritis is to date restricted to infectious etiology and managed with antibiotics. Conversely, the concept of impaired inflammatory state of the endometrium (IISE) provides a more global approach to defective endometrial inflammation, considering both infectious and non-infectious etiology. A non-systematic review was done through a search on MEDLINE, EMBASE, Global Health, The Cochrane Library, Health Technology Assessment Database and Web of Science, research registers. Pertinent original and review articles, published in English or French until December 31, 2019, were selected. A compelling body of evidence demonstrates transient, repeated and persistent IISE to be a major factor of most problematic disorders in obstetrics/gynecology, such as endometrial polyps, unexplained infertility, miscarriage, placenta-related pathology and endometrial cancer. When scheduled accordingly, hysteroscopy can play a key role in the IISE assessment. Robust data suggests the pertinence of minimal-effective anti-inflammatory regimens for therapeutic IISE targeting. This review provides a comprehensive update on the multiple facets of inflammation in the endometrial physiology and pathology. Further research is needed to improve classification, diagnosis and treatment of IISE. Termedia Publishing House 2020-07-13 2020-07 /pmc/articles/PMC7422289/ /pubmed/32802019 http://dx.doi.org/10.5114/pm.2020.97863 Text en Copyright © 2020 Termedia http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/) |
spellingShingle | Review Paper Drizi, Amal Djokovic, Dusan Laganà, Antonio Simone van Herendael, Bruno Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. Current insights and future directions |
title | Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. Current insights and future directions |
title_full | Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. Current insights and future directions |
title_fullStr | Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. Current insights and future directions |
title_full_unstemmed | Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. Current insights and future directions |
title_short | Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. Current insights and future directions |
title_sort | impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. current insights and future directions |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422289/ https://www.ncbi.nlm.nih.gov/pubmed/32802019 http://dx.doi.org/10.5114/pm.2020.97863 |
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