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Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries
BACKGROUND: Topologically associating domains (TADs) are genomic regions of self-interaction. Additionally, it is known that TAD boundaries are enriched in CTCF binding sites. In turn, CTCF sites are known to be asymmetric, whereby the convergent configuration of a pair of CTCF sites leads to the fo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422557/ https://www.ncbi.nlm.nih.gov/pubmed/32782014 http://dx.doi.org/10.1186/s13059-020-02108-x |