Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation

BACKGROUND: Neurodegeneration is a representative phenotype of patients with chronic alcoholism. Ethanol-induced calcium overload causes NOD-like receptor protein 3 (NLRP3) inflammasome formation and an imbalance in mitochondrial dynamics, closely associated with the pathogenesis of neurodegeneratio...

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Detalles Bibliográficos
Autores principales: Lim, Jae Ryong, Lee, Hyun Jik, Jung, Young Hyun, Kim, Jun Sung, Chae, Chang Woo, Kim, Seo Yihl, Han, Ho Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422600/
https://www.ncbi.nlm.nih.gov/pubmed/32787872
http://dx.doi.org/10.1186/s12964-020-00572-3

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