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Exposure to Road Traffic Noise and Incidence of Acute Myocardial Infarction and Congestive Heart Failure: A Population-Based Cohort Study in Toronto, Canada

BACKGROUND: Epidemiological evidence for the association between traffic-related noise and the incidence of major cardiovascular events such as acute myocardial infarction (AMI) and congestive heart failure (CHF) is inconclusive, especially in North America. OBJECTIVES: We evaluated the associations...

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Autores principales: Bai, Li, Shin, Saeha, Oiamo, Tor H., Burnett, Richard T., Weichenthal, Scott, Jerrett, Michael, Kwong, Jeffrey C., Copes, Ray, Kopp, Alexander, Chen, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422718/
https://www.ncbi.nlm.nih.gov/pubmed/32783534
http://dx.doi.org/10.1289/EHP5809
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author Bai, Li
Shin, Saeha
Oiamo, Tor H.
Burnett, Richard T.
Weichenthal, Scott
Jerrett, Michael
Kwong, Jeffrey C.
Copes, Ray
Kopp, Alexander
Chen, Hong
author_facet Bai, Li
Shin, Saeha
Oiamo, Tor H.
Burnett, Richard T.
Weichenthal, Scott
Jerrett, Michael
Kwong, Jeffrey C.
Copes, Ray
Kopp, Alexander
Chen, Hong
author_sort Bai, Li
collection PubMed
description BACKGROUND: Epidemiological evidence for the association between traffic-related noise and the incidence of major cardiovascular events such as acute myocardial infarction (AMI) and congestive heart failure (CHF) is inconclusive, especially in North America. OBJECTIVES: We evaluated the associations between long-term exposure to road traffic noise and the incidence of AMI and CHF. METHODS: Our study population comprised [Formula: see text] people 30–100 years of age who lived in Toronto, Canada, from 2001 to 2015 and were free of AMI (referred to as the AMI cohort) or CHF (the CHF cohort) at baseline. Outcomes were ascertained from health administrative databases using validated algorithms. Annual average noise levels were estimated as the A-weighted equivalent sound pressure level over the 24-h period (LAeq24) and during nighttime (LAeqNight), respectively, using propagation modeling, and assigned to participants’ annual six-digit postal code addresses during follow-up. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for incident AMI and CHF in relation to LAeq24 and LAeqNight using random-effects Cox proportional hazards models adjusting for individual- and census tract–level covariates, including traffic-related air pollutants [e.g., ultrafine particles (UFPs) and nitrogen dioxide]. RESULTS: During follow-up, there were 37,441 AMI incident cases and 95,138 CHF incident cases. Each interquartile range change in LAeq24 was associated with an increased risk of incident AMI ([Formula: see text]; 95% CI: 1.06, 1.08) and CHF ([Formula: see text]; 95% CI: 1.06, 1.09). Similarly, LAeqNight was associated with incident AMI ([Formula: see text]; 95% CI: 1.05, 1.08) and CHF ([Formula: see text]; 95% CI: 1.05, 1.07). These results were robust to various sensitivity analyses and remained elevated after controlling for long-term exposure to UFPs and nitrogen dioxide. We found near-linear relationships between noise and the incidence of AMI and CHF with no evidence of threshold values. CONCLUSION: In this large cohort study in Toronto, Canada, chronic exposure to road traffic noise was associated with elevated risks for AMI and CHF incidence. https://doi.org/10.1289/EHP5809
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spelling pubmed-74227182020-08-17 Exposure to Road Traffic Noise and Incidence of Acute Myocardial Infarction and Congestive Heart Failure: A Population-Based Cohort Study in Toronto, Canada Bai, Li Shin, Saeha Oiamo, Tor H. Burnett, Richard T. Weichenthal, Scott Jerrett, Michael Kwong, Jeffrey C. Copes, Ray Kopp, Alexander Chen, Hong Environ Health Perspect Research BACKGROUND: Epidemiological evidence for the association between traffic-related noise and the incidence of major cardiovascular events such as acute myocardial infarction (AMI) and congestive heart failure (CHF) is inconclusive, especially in North America. OBJECTIVES: We evaluated the associations between long-term exposure to road traffic noise and the incidence of AMI and CHF. METHODS: Our study population comprised [Formula: see text] people 30–100 years of age who lived in Toronto, Canada, from 2001 to 2015 and were free of AMI (referred to as the AMI cohort) or CHF (the CHF cohort) at baseline. Outcomes were ascertained from health administrative databases using validated algorithms. Annual average noise levels were estimated as the A-weighted equivalent sound pressure level over the 24-h period (LAeq24) and during nighttime (LAeqNight), respectively, using propagation modeling, and assigned to participants’ annual six-digit postal code addresses during follow-up. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for incident AMI and CHF in relation to LAeq24 and LAeqNight using random-effects Cox proportional hazards models adjusting for individual- and census tract–level covariates, including traffic-related air pollutants [e.g., ultrafine particles (UFPs) and nitrogen dioxide]. RESULTS: During follow-up, there were 37,441 AMI incident cases and 95,138 CHF incident cases. Each interquartile range change in LAeq24 was associated with an increased risk of incident AMI ([Formula: see text]; 95% CI: 1.06, 1.08) and CHF ([Formula: see text]; 95% CI: 1.06, 1.09). Similarly, LAeqNight was associated with incident AMI ([Formula: see text]; 95% CI: 1.05, 1.08) and CHF ([Formula: see text]; 95% CI: 1.05, 1.07). These results were robust to various sensitivity analyses and remained elevated after controlling for long-term exposure to UFPs and nitrogen dioxide. We found near-linear relationships between noise and the incidence of AMI and CHF with no evidence of threshold values. CONCLUSION: In this large cohort study in Toronto, Canada, chronic exposure to road traffic noise was associated with elevated risks for AMI and CHF incidence. https://doi.org/10.1289/EHP5809 Environmental Health Perspectives 2020-08-12 /pmc/articles/PMC7422718/ /pubmed/32783534 http://dx.doi.org/10.1289/EHP5809 Text en https://ehp.niehs.nih.gov/about-ehp/license EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
spellingShingle Research
Bai, Li
Shin, Saeha
Oiamo, Tor H.
Burnett, Richard T.
Weichenthal, Scott
Jerrett, Michael
Kwong, Jeffrey C.
Copes, Ray
Kopp, Alexander
Chen, Hong
Exposure to Road Traffic Noise and Incidence of Acute Myocardial Infarction and Congestive Heart Failure: A Population-Based Cohort Study in Toronto, Canada
title Exposure to Road Traffic Noise and Incidence of Acute Myocardial Infarction and Congestive Heart Failure: A Population-Based Cohort Study in Toronto, Canada
title_full Exposure to Road Traffic Noise and Incidence of Acute Myocardial Infarction and Congestive Heart Failure: A Population-Based Cohort Study in Toronto, Canada
title_fullStr Exposure to Road Traffic Noise and Incidence of Acute Myocardial Infarction and Congestive Heart Failure: A Population-Based Cohort Study in Toronto, Canada
title_full_unstemmed Exposure to Road Traffic Noise and Incidence of Acute Myocardial Infarction and Congestive Heart Failure: A Population-Based Cohort Study in Toronto, Canada
title_short Exposure to Road Traffic Noise and Incidence of Acute Myocardial Infarction and Congestive Heart Failure: A Population-Based Cohort Study in Toronto, Canada
title_sort exposure to road traffic noise and incidence of acute myocardial infarction and congestive heart failure: a population-based cohort study in toronto, canada
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422718/
https://www.ncbi.nlm.nih.gov/pubmed/32783534
http://dx.doi.org/10.1289/EHP5809
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