The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

The Krebs cycle-derived metabolite itaconate is highly upregulated in inflammatory macrophages and exerts immunomodulatory effects through cysteine modifications on target proteins. The NLRP3 inflammasome, which cleaves IL-1β, IL-18, and gasdermin D, must be tightly regulated to avoid excessive infl...

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Detalles Bibliográficos
Autores principales: Hooftman, Alexander, Angiari, Stefano, Hester, Svenja, Corcoran, Sarah E., Runtsch, Marah C., Ling, Chris, Ruzek, Melanie C., Slivka, Peter F., McGettrick, Anne F., Banahan, Kathy, Hughes, Mark M., Irvine, Alan D., Fischer, Roman, O’Neill, Luke A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422798/
https://www.ncbi.nlm.nih.gov/pubmed/32791101
http://dx.doi.org/10.1016/j.cmet.2020.07.016

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