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Diacylglycerol acyltransferase 1/2 inhibition induces dysregulation of fatty acid metabolism and leads to intestinal barrier failure and diarrhea in mice

The intestinal metabolism and transport of triacylglycerol (TAG) play a critical role in dietary TAG absorption, and defects in the process are associated with congenital diarrhea. The final reaction in TAG synthesis is catalyzed by diacylglycerol acyltransferase (DGAT1 and DGAT2), which uses activa...

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Detalles Bibliográficos
Autores principales:	Takemoto, Kosuke, Fukasaka, Yumiko, Yoshimoto, Ryo, Nambu, Hirohide, Yukioka, Hideo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422801/ https://www.ncbi.nlm.nih.gov/pubmed/32786057 http://dx.doi.org/10.14814/phy2.14542

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