Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities

PURPOSE: Accumulation of the long noncoding Alu element RNA activates the NLRP3 inflammasome and leads to retinal pigment epithelium (RPE) cell death, a key event in the pathogenesis of geographic atrophy during late-stage age-related macular degeneration. Lamivudine (3TC) is a nucleoside analog rev...

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Detalles Bibliográficos
Autores principales: Yamada, Kazuhisa, Kaneko, Hiroki, Shimizu, Hideyuki, Suzumura, Ayana, Namba, Rina, Takayama, Kei, Ito, Seina, Sugimoto, Masataka, Terasaki, Hiroko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422901/
https://www.ncbi.nlm.nih.gov/pubmed/32855848
http://dx.doi.org/10.1167/tvst.9.8.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422901/
https://www.ncbi.nlm.nih.gov/pubmed/32855848
http://dx.doi.org/10.1167/tvst.9.8.1

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