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Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities

PURPOSE: Accumulation of the long noncoding Alu element RNA activates the NLRP3 inflammasome and leads to retinal pigment epithelium (RPE) cell death, a key event in the pathogenesis of geographic atrophy during late-stage age-related macular degeneration. Lamivudine (3TC) is a nucleoside analog rev...

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Detalles Bibliográficos
Autores principales:	Yamada, Kazuhisa, Kaneko, Hiroki, Shimizu, Hideyuki, Suzumura, Ayana, Namba, Rina, Takayama, Kei, Ito, Seina, Sugimoto, Masataka, Terasaki, Hiroko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422901/ https://www.ncbi.nlm.nih.gov/pubmed/32855848 http://dx.doi.org/10.1167/tvst.9.8.1

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