Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19

[Image: see text] Four of five different monoclonal antibodies (mAbs) that have been crystallized in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S) have remarkably similar primary and secondary loop structures at the heavy chain complementarity-determining regions...

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Autores principales: Mi, Tianxiong, Burgess, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423023/
https://www.ncbi.nlm.nih.gov/pubmed/32934769
http://dx.doi.org/10.1021/acsmedchemlett.0c00409
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author Mi, Tianxiong
Burgess, Kevin
author_facet Mi, Tianxiong
Burgess, Kevin
author_sort Mi, Tianxiong
collection PubMed
description [Image: see text] Four of five different monoclonal antibodies (mAbs) that have been crystallized in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S) have remarkably similar primary and secondary loop structures at the heavy chain complementarity-determining regions (HCDR) 1 and 2. All these reports give a structural basis for the deceptively difficult problem of accurate peptidomimetic loop mimic design.
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spelling pubmed-74230232020-08-12 Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19 Mi, Tianxiong Burgess, Kevin ACS Med Chem Lett [Image: see text] Four of five different monoclonal antibodies (mAbs) that have been crystallized in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S) have remarkably similar primary and secondary loop structures at the heavy chain complementarity-determining regions (HCDR) 1 and 2. All these reports give a structural basis for the deceptively difficult problem of accurate peptidomimetic loop mimic design. American Chemical Society 2020-08-10 /pmc/articles/PMC7423023/ /pubmed/32934769 http://dx.doi.org/10.1021/acsmedchemlett.0c00409 Text en Copyright © 2020 American Chemical Society This article is made available via the ACS COVID-19 subset (https://pubs.acs.org/page/vi/chemistry_coronavirus_research) for unrestricted RESEARCH re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Mi, Tianxiong
Burgess, Kevin
Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19
title Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19
title_full Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19
title_fullStr Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19
title_full_unstemmed Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19
title_short Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19
title_sort striking similarities between cdrs in some mabs that neutralize covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423023/
https://www.ncbi.nlm.nih.gov/pubmed/32934769
http://dx.doi.org/10.1021/acsmedchemlett.0c00409
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