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A new method for estimating HIV incidence from a single cross-sectional survey

Estimating incidence from cross-sectional data sources is both important to the understanding of the HIV epidemic and challenging from a methodological standpoint. We develop a new incidence estimator that measures the size of the undiagnosed population and the amount of time spent undiagnosed in or...

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Autores principales: Fellows, Ian E., Shiraishi, Ray W., Cherutich, Peter, Achia, Thomas, Young, Peter W., Kim, Andrea A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423136/
https://www.ncbi.nlm.nih.gov/pubmed/32785257
http://dx.doi.org/10.1371/journal.pone.0237221
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author Fellows, Ian E.
Shiraishi, Ray W.
Cherutich, Peter
Achia, Thomas
Young, Peter W.
Kim, Andrea A.
author_facet Fellows, Ian E.
Shiraishi, Ray W.
Cherutich, Peter
Achia, Thomas
Young, Peter W.
Kim, Andrea A.
author_sort Fellows, Ian E.
collection PubMed
description Estimating incidence from cross-sectional data sources is both important to the understanding of the HIV epidemic and challenging from a methodological standpoint. We develop a new incidence estimator that measures the size of the undiagnosed population and the amount of time spent undiagnosed in order to infer incidence and transmission rates. The estimator is calculated using commonly collected information on testing history and HIV status and, thus, can be deployed in many HIV surveys without additional cost. If ART biomarker status and/or viral load information is available, the estimator can be adjusted for biases in self-reported testing history. The performance of the estimator is explored in two large surveys in Kenya, where we find our point estimates to be consistent with assay-derived estimates, with much smaller standard errors.
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spelling pubmed-74231362020-08-20 A new method for estimating HIV incidence from a single cross-sectional survey Fellows, Ian E. Shiraishi, Ray W. Cherutich, Peter Achia, Thomas Young, Peter W. Kim, Andrea A. PLoS One Research Article Estimating incidence from cross-sectional data sources is both important to the understanding of the HIV epidemic and challenging from a methodological standpoint. We develop a new incidence estimator that measures the size of the undiagnosed population and the amount of time spent undiagnosed in order to infer incidence and transmission rates. The estimator is calculated using commonly collected information on testing history and HIV status and, thus, can be deployed in many HIV surveys without additional cost. If ART biomarker status and/or viral load information is available, the estimator can be adjusted for biases in self-reported testing history. The performance of the estimator is explored in two large surveys in Kenya, where we find our point estimates to be consistent with assay-derived estimates, with much smaller standard errors. Public Library of Science 2020-08-12 /pmc/articles/PMC7423136/ /pubmed/32785257 http://dx.doi.org/10.1371/journal.pone.0237221 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Fellows, Ian E.
Shiraishi, Ray W.
Cherutich, Peter
Achia, Thomas
Young, Peter W.
Kim, Andrea A.
A new method for estimating HIV incidence from a single cross-sectional survey
title A new method for estimating HIV incidence from a single cross-sectional survey
title_full A new method for estimating HIV incidence from a single cross-sectional survey
title_fullStr A new method for estimating HIV incidence from a single cross-sectional survey
title_full_unstemmed A new method for estimating HIV incidence from a single cross-sectional survey
title_short A new method for estimating HIV incidence from a single cross-sectional survey
title_sort new method for estimating hiv incidence from a single cross-sectional survey
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423136/
https://www.ncbi.nlm.nih.gov/pubmed/32785257
http://dx.doi.org/10.1371/journal.pone.0237221
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