BK Virus Nephropathy: Prevalence, Impact and Management Strategies

BK virus reactivation as a result of therapeutic immunosuppression following renal transplant can result in BK polyomavirus nephropathy and renal allograft loss. This is a complex and challenging clinical problem with a range of management options and practices reported in literature. The current st...

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Autores principales: Sharma, Rajeev, Zachariah, Mareena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423353/
https://www.ncbi.nlm.nih.gov/pubmed/32821148
http://dx.doi.org/10.2147/IJNRD.S236556
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author Sharma, Rajeev
Zachariah, Mareena
author_facet Sharma, Rajeev
Zachariah, Mareena
author_sort Sharma, Rajeev
collection PubMed
description BK virus reactivation as a result of therapeutic immunosuppression following renal transplant can result in BK polyomavirus nephropathy and renal allograft loss. This is a complex and challenging clinical problem with a range of management options and practices reported in literature. The current standard for early diagnosis and treatment is surveillance by measuring viral DNA in blood using qPCR. Immunosuppression reduction is the cornerstone of effective management but is associated with a risk of acute rejection following treatment.
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spelling pubmed-74233532020-08-19 BK Virus Nephropathy: Prevalence, Impact and Management Strategies Sharma, Rajeev Zachariah, Mareena Int J Nephrol Renovasc Dis Review BK virus reactivation as a result of therapeutic immunosuppression following renal transplant can result in BK polyomavirus nephropathy and renal allograft loss. This is a complex and challenging clinical problem with a range of management options and practices reported in literature. The current standard for early diagnosis and treatment is surveillance by measuring viral DNA in blood using qPCR. Immunosuppression reduction is the cornerstone of effective management but is associated with a risk of acute rejection following treatment. Dove 2020-08-07 /pmc/articles/PMC7423353/ /pubmed/32821148 http://dx.doi.org/10.2147/IJNRD.S236556 Text en © 2020 Sharma and Zachariah. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Sharma, Rajeev
Zachariah, Mareena
BK Virus Nephropathy: Prevalence, Impact and Management Strategies
title BK Virus Nephropathy: Prevalence, Impact and Management Strategies
title_full BK Virus Nephropathy: Prevalence, Impact and Management Strategies
title_fullStr BK Virus Nephropathy: Prevalence, Impact and Management Strategies
title_full_unstemmed BK Virus Nephropathy: Prevalence, Impact and Management Strategies
title_short BK Virus Nephropathy: Prevalence, Impact and Management Strategies
title_sort bk virus nephropathy: prevalence, impact and management strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423353/
https://www.ncbi.nlm.nih.gov/pubmed/32821148
http://dx.doi.org/10.2147/IJNRD.S236556
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