Tumor-Derived Exosome-Educated Hepatic Stellate Cells Regulate Lactate Metabolism of Hypoxic Colorectal Tumor Cells via the IL-6/STAT3 Pathway to Confer Drug Resistance

PURPOSE: Colorectal cancer cells spread to the liver and crosstalk with the microenvironment, and hepatic stellate cells (HSCs) are the major stromal components in the liver. However, the role of the interaction between colorectal tumor cells and HSCs in chemotherapeutic resistance remains unclear....

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Detalles Bibliográficos
Autores principales: Li, Feifei, Zhan, Lei, Dong, Qian, Wang, Qiwei, Wang, Yuanhe, Li, Xiaoyan, Zhang, Yong, Zhang, Jingdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423356/
https://www.ncbi.nlm.nih.gov/pubmed/32821126
http://dx.doi.org/10.2147/OTT.S253485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423356/
https://www.ncbi.nlm.nih.gov/pubmed/32821126
http://dx.doi.org/10.2147/OTT.S253485

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