Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits

Switches between global sleep and wakefulness states are believed to be dictated by top-down influences arising from subcortical nuclei. Using forward genetics and in vivo electrophysiology, we identified a recessive mouse mutant line characterized by a substantially reduced propensity to transition...

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Detalles Bibliográficos
Autores principales: Banks, Gareth T., Guillaumin, Mathilde C. C., Heise, Ines, Lau, Petrina, Yin, Minghui, Bourbia, Nora, Aguilar, Carlos, Bowl, Michael R., Esapa, Chris, Brown, Laurence A., Hasan, Sibah, Tagliatti, Erica, Nicholson, Elizabeth, Bains, Rasneer Sonia, Wells, Sara, Vyazovskiy, Vladyslav V., Volynski, Kirill, Peirson, Stuart N., Nolan, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423362/
https://www.ncbi.nlm.nih.gov/pubmed/32851175
http://dx.doi.org/10.1126/sciadv.abb3567

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