EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways

Mutations in the polycomb repressive complex 2 (PRC2) can cause Weaver-like syndrome, wherein a patient cohort exhibits abnormal white matter; however, PRC2 functions in CNS myelination and regeneration remain elusive. We show here that H3K27me3, the PRC2 catalytic product, increases during oligoden...

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Detalles Bibliográficos
Autores principales: Wang, Jiajia, Yang, Lijun, Dong, Chen, Wang, Jincheng, Xu, Lingli, Qiu, Yueping, Weng, Qinjie, Zhao, Chuntao, Xin, Mei, Lu, Q. Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423366/
https://www.ncbi.nlm.nih.gov/pubmed/32851157
http://dx.doi.org/10.1126/sciadv.aaz6477

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