Cryo-EM structures of SERCA2b reveal the mechanism of regulation by the luminal extension tail

Sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) pumps Ca(2+) from the cytosol into the ER and maintains the cellular calcium homeostasis. Herein, we present cryo–electron microscopy (cryo-EM) structures of human SERCA2b in E1∙2Ca(2+)–adenylyl methylenediphosphonate (AMPPCP) and E2-BeF(3)(−) states...

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Detalles Bibliográficos
Autores principales: Zhang, Yuxia, Inoue, Michio, Tsutsumi, Akihisa, Watanabe, Satoshi, Nishizawa, Tomohiro, Nagata, Kazuhiro, Kikkawa, Masahide, Inaba, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423393/
https://www.ncbi.nlm.nih.gov/pubmed/32851169
http://dx.doi.org/10.1126/sciadv.abb0147

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