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Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

Calcium (Ca(2+)) influx into mitochondria occurs through a Ca(2+)-selective uniporter channel, which regulates essential cellular processes in eukaryotic organisms. Previous evolutionary analyses of its pore-forming subunits MCU and EMRE, and gatekeeper MICU1, pinpointed an evolutionary paradox: the...

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Detalles Bibliográficos
Autores principales:	Pittis, Alexandros A., Goh, Valerie, Cebrian-Serrano, Alberto, Wettmarshausen, Jennifer, Perocchi, Fabiana, Gabaldón, Toni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423614/ https://www.ncbi.nlm.nih.gov/pubmed/32788582 http://dx.doi.org/10.1038/s41467-020-17705-4

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