Cargando…

Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter

Calcium (Ca(2+)) influx into mitochondria occurs through a Ca(2+)-selective uniporter channel, which regulates essential cellular processes in eukaryotic organisms. Previous evolutionary analyses of its pore-forming subunits MCU and EMRE, and gatekeeper MICU1, pinpointed an evolutionary paradox: the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pittis, Alexandros A., Goh, Valerie, Cebrian-Serrano, Alberto, Wettmarshausen, Jennifer, Perocchi, Fabiana, Gabaldón, Toni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423614/ https://www.ncbi.nlm.nih.gov/pubmed/32788582 http://dx.doi.org/10.1038/s41467-020-17705-4

Ejemplares similares

Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex
por: Van Keuren, Anna M., et al.
Publicado: (2020)

Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes
por: Gabaldón, Toni, et al.
Publicado: (2015)

Late acquisition of mitochondria by a host with chimeric prokaryotic ancestry
por: Pittis, Alexandros A., et al.
Publicado: (2016)

Quantitative analysis of mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE) in mitochondria from mouse tissues and HeLa cells
por: Watanabe, Akira, et al.
Publicado: (2022)

Antisense artifacts in transcriptome microarray experiments are resolved by actinomycin D
por: Perocchi, Fabiana, et al.
Publicado: (2007)

Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU
por: MacEwen, Melissa JS, et al.
Publicado: (2020)

Shared evolutionary footprints suggest mitochondrial oxidative damage underlies multiple complex I losses in fungi
por: Schikora-Tamarit, Miquel Àngel, et al.
Publicado: (2021)

Resolving the True Ventricular Mural Architecture
por: Stephenson, Robert S., et al.
Publicado: (2018)

Does Structural Color Exist in True Fungi?
por: Brodie, Juliet, et al.
Publicado: (2021)

Architecture of the Mitochondrial Calcium Uniporter
por: Oxenoid, Kirill, et al.
Publicado: (2016)

EMR in Eye Units
por: Camburu, Georgiana, et al.
Publicado: (2020)

Resolving evolutionary relationships in lichen-forming fungi using diverse phylogenomic datasets and analytical approaches
por: Leavitt, Steven D., et al.
Publicado: (2016)

Alternative Carrier Solvents for Pigments Extracted from Spalting Fungi
por: Pittis, Lauren, et al.
Publicado: (2018)

The ‘Anchoring-EMR’ technique has already been described and named the ‘Tip-in EMR’ technique
por: Imai, Kenichiro, et al.
Publicado: (2020)

Combining structured and unstructured data in EMRs to create clinically-defined EMR-derived cohorts
por: Tam, Charmaine S., et al.
Publicado: (2021)

Fungal evolution: diversity, taxonomy and phylogeny of the Fungi
por: Naranjo‐Ortiz, Miguel A., et al.
Publicado: (2019)

Immunization registries in the EMR Era
por: Stevens, Lindsay A., et al.
Publicado: (2013)

Asymmetric protonation of EmrE
por: Morrison, Emma A., et al.
Publicado: (2015)

The transition to uniportal robotic surgery in the second decade of uniportal surgery
por: Ismail, Mahmoud, et al.
Publicado: (2023)

Evolutionary and Genomic Diversity of True Polyploidy in Tetrapods
por: Mezzasalma, Marcello, et al.
Publicado: (2023)

ProtPhylo: identification of protein–phenotype and protein–protein functional associations via phylogenetic profiling
por: Cheng, Yiming, et al.
Publicado: (2015)

EmrR-Dependent Upregulation of the Efflux Pump EmrCAB Contributes to Antibiotic Resistance in Chromobacterium violaceum
por: Barroso, Kelly C. M., et al.
Publicado: (2018)

Evolutionary considerations on the origin of peroxisomes from the endoplasmic reticulum, and their relationships with mitochondria
por: Gabaldón, Toni
Publicado: (2014)

A metabolic scenario for the evolutionary origin of peroxisomes from the endomembranous system
por: Gabaldón, Toni
Publicado: (2013)

Cryo-EM structure of the mitochondrial calcium uniporter
por: Nguyen, Nam X., et al.
Publicado: (2018)

The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders
por: Liao, Yajin, et al.
Publicado: (2017)

Horizontal acquisition of toxic alkaloid synthesis in a clade of plant associated fungi
por: Marcet-Houben, Marina, et al.
Publicado: (2016)

An emerging consensus for the structure of EmrE
por: Korkhov, Vladimir M., et al.
Publicado: (2009)

EMR of large periampullary neuroendocrine tumor
por: Nelsen, Eric M., et al.
Publicado: (2017)

Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens
por: Ksiezopolska, Ewa, et al.
Publicado: (2018)

Stress-Electromagnetic Radiation (EMR) Numerical Model and EMR Evolution Law of Composite Coal-Rock under Load
por: Li, Xin, et al.
Publicado: (2022)

Inflated Impact Factors? The True Impact of Evolutionary Papers in Non-Evolutionary Journals
por: Postma, Erik
Publicado: (2007)

Discovery Mondays: Quantum physics - incredible but true
Publicado: (2006)

The future of the uniportal approach
por: Siu, Ivan C. H., et al.
Publicado: (2022)

Phylogenomics supports microsporidia as the earliest diverging clade of sequenced fungi
por: Capella-Gutiérrez, Salvador, et al.
Publicado: (2012)

Evolution of substrate specificity in the Nucleobase-Ascorbate Transporter (NAT) protein family
por: Kourkoulou, Anezia, et al.
Publicado: (2018)

Estimating true evolutionary distances under the DCJ model
por: Lin, Yu, et al.
Publicado: (2008)

Cercosporoid fungi (Mycosphaerellaceae) 3. Species on monocots (Poaceae, true grasses)
por: Braun, Uwe, et al.
Publicado: (2015)

Regulatory mechanisms of mitochondrial calcium uptake by the calcium uniporter complex
por: Yamada, Akiko, et al.
Publicado: (2023)

OpenMRS as an emergency EMR—How we used a global good to create an emergency EMR in a week
por: Mamlin, Burke W., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jjm5g2dfi250k025rvqjihe7g0