Dysregulation of ghrelin in diabetes impairs the vascular reparative response to hindlimb ischemia in a mouse model; clinical relevance to peripheral artery disease

Type 2 diabetes is a prominent risk factor for peripheral artery disease (PAD). Yet, the mechanistic link between diabetes and PAD remains unclear. This study proposes that dysregulation of the endogenous hormone ghrelin, a potent modulator of vascular function, underpins the causal link between dia...

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Detalles Bibliográficos
Autores principales: Neale, Joshua P. H., Pearson, James T., Thomas, Kate N., Tsuchimochi, Hirotsugu, Hosoda, Hiroshi, Kojima, Masayasu, Sato, Takahiro, Jones, Gregory T., Denny, Adam P., Daniels, Lorna J., Chandrasekera, Dhananjie, Liu, Ping, van Rij, Andre M., Katare, Rajesh, Schwenke, Daryl O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423620/
https://www.ncbi.nlm.nih.gov/pubmed/32788622
http://dx.doi.org/10.1038/s41598-020-70391-6

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