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Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence

Schizophrenia (SCZ) is associated with an increased risk of violence compared to the general population. Previous studies have indicated smaller hippocampal and amygdala volumes in violent than non-violent psychotic patients(.) However, little is known about volumetric differences at the subdivision...

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Autores principales: Tesli, Natalia, van der Meer, Dennis, Rokicki, Jaroslav, Storvestre, Guttorm, Røsæg, Cato, Jensen, Arvid, Hjell, Gabriela, Bell, Christina, Fischer-Vieler, Thomas, Tesli, Martin, Andreassen, Ole A., Melle, Ingrid, Agartz, Ingrid, Haukvik, Unn K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423802/
https://www.ncbi.nlm.nih.gov/pubmed/31980898
http://dx.doi.org/10.1007/s00406-020-01098-y
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author Tesli, Natalia
van der Meer, Dennis
Rokicki, Jaroslav
Storvestre, Guttorm
Røsæg, Cato
Jensen, Arvid
Hjell, Gabriela
Bell, Christina
Fischer-Vieler, Thomas
Tesli, Martin
Andreassen, Ole A.
Melle, Ingrid
Agartz, Ingrid
Haukvik, Unn K.
author_facet Tesli, Natalia
van der Meer, Dennis
Rokicki, Jaroslav
Storvestre, Guttorm
Røsæg, Cato
Jensen, Arvid
Hjell, Gabriela
Bell, Christina
Fischer-Vieler, Thomas
Tesli, Martin
Andreassen, Ole A.
Melle, Ingrid
Agartz, Ingrid
Haukvik, Unn K.
author_sort Tesli, Natalia
collection PubMed
description Schizophrenia (SCZ) is associated with an increased risk of violence compared to the general population. Previous studies have indicated smaller hippocampal and amygdala volumes in violent than non-violent psychotic patients(.) However, little is known about volumetric differences at the subdivision level of these structures. In the present study, hippocampal subfields and amygdala nuclei volumes were estimated with FreeSurfer from 3 T MRI of SCZ patients with (SCZ-V, n = 24) and without (SCZ-NV, n = 51) a history of severe violence and 90 healthy controls (HC). Volumetric differences between groups were explored with a general linear model covarying for confounders, in addition to follow-up analyses in patient groups controlling for clinical characteristics such as antipsychotic medication, duration of illness and illicit substance use. SCZ-V had smaller total hippocampal volume and smaller CA1, HATA, fimbria, and molecular layer of DG volumes compared to HC. Total amygdala volume together with basal nucleus, accessory basal nucleus, CTA, and paralaminar nucleus volumes were smaller in SCZ-V compared to HC. In SCZ-NV, compared to HC, the observed smaller volumes were limited to basal and paralaminar nucleus. There were no significant differences in hippocampal subfield and amygdala nuclei volumes between SCZ-V and SCZ-NV. Follow-up analyses showed that the results in patient groups were not affected by clinical characteristics. The results suggest that smaller hippocampal subfield and amygdala nuclei volumes may be relevant to violence risk in SCZ. However, the neurobiological signature of violence in SCZ should be further investigated in larger cohorts. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00406-020-01098-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-74238022020-08-18 Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence Tesli, Natalia van der Meer, Dennis Rokicki, Jaroslav Storvestre, Guttorm Røsæg, Cato Jensen, Arvid Hjell, Gabriela Bell, Christina Fischer-Vieler, Thomas Tesli, Martin Andreassen, Ole A. Melle, Ingrid Agartz, Ingrid Haukvik, Unn K. Eur Arch Psychiatry Clin Neurosci Original Paper Schizophrenia (SCZ) is associated with an increased risk of violence compared to the general population. Previous studies have indicated smaller hippocampal and amygdala volumes in violent than non-violent psychotic patients(.) However, little is known about volumetric differences at the subdivision level of these structures. In the present study, hippocampal subfields and amygdala nuclei volumes were estimated with FreeSurfer from 3 T MRI of SCZ patients with (SCZ-V, n = 24) and without (SCZ-NV, n = 51) a history of severe violence and 90 healthy controls (HC). Volumetric differences between groups were explored with a general linear model covarying for confounders, in addition to follow-up analyses in patient groups controlling for clinical characteristics such as antipsychotic medication, duration of illness and illicit substance use. SCZ-V had smaller total hippocampal volume and smaller CA1, HATA, fimbria, and molecular layer of DG volumes compared to HC. Total amygdala volume together with basal nucleus, accessory basal nucleus, CTA, and paralaminar nucleus volumes were smaller in SCZ-V compared to HC. In SCZ-NV, compared to HC, the observed smaller volumes were limited to basal and paralaminar nucleus. There were no significant differences in hippocampal subfield and amygdala nuclei volumes between SCZ-V and SCZ-NV. Follow-up analyses showed that the results in patient groups were not affected by clinical characteristics. The results suggest that smaller hippocampal subfield and amygdala nuclei volumes may be relevant to violence risk in SCZ. However, the neurobiological signature of violence in SCZ should be further investigated in larger cohorts. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00406-020-01098-y) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-01-24 2020 /pmc/articles/PMC7423802/ /pubmed/31980898 http://dx.doi.org/10.1007/s00406-020-01098-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Paper
Tesli, Natalia
van der Meer, Dennis
Rokicki, Jaroslav
Storvestre, Guttorm
Røsæg, Cato
Jensen, Arvid
Hjell, Gabriela
Bell, Christina
Fischer-Vieler, Thomas
Tesli, Martin
Andreassen, Ole A.
Melle, Ingrid
Agartz, Ingrid
Haukvik, Unn K.
Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence
title Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence
title_full Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence
title_fullStr Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence
title_full_unstemmed Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence
title_short Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence
title_sort hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423802/
https://www.ncbi.nlm.nih.gov/pubmed/31980898
http://dx.doi.org/10.1007/s00406-020-01098-y
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