Postinfectious Autoimmune Hepatitis-Induced Liver Failure: A Consequence of Hepatitis A Virus Infection

Autoimmune hepatitis (AIH) is a chronic inflammatory immune-mediated hepatic pathology of unclear etiology. The mechanisms initiating and driving autoimmune inflammation of the liver and the loss of hepatic tolerance are still elusive. Several studies have documented the involvement of genetic facto...

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Autores principales: Subramanian, Sruthi Kapliyil, Patel, Jigar M., Younes, Mamoun, Nevah Rubin, Moises I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423909/
https://www.ncbi.nlm.nih.gov/pubmed/32821769
http://dx.doi.org/10.14309/crj.0000000000000441
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author Subramanian, Sruthi Kapliyil
Patel, Jigar M.
Younes, Mamoun
Nevah Rubin, Moises I.
author_facet Subramanian, Sruthi Kapliyil
Patel, Jigar M.
Younes, Mamoun
Nevah Rubin, Moises I.
author_sort Subramanian, Sruthi Kapliyil
collection PubMed
description Autoimmune hepatitis (AIH) is a chronic inflammatory immune-mediated hepatic pathology of unclear etiology. The mechanisms initiating and driving autoimmune inflammation of the liver and the loss of hepatic tolerance are still elusive. Several studies have documented the involvement of genetic factors and triggering agents such as toxic injury, treatment with immune-modifying drugs, or previous viral infections with perhaps strongest evidence for the hepatitis C virus. Rarely, AIH has been reported to develop after hepatitis A virus infection. We describe a case of de novo AIH in a patient with a history of recent hepatitis A virus infection.
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spelling pubmed-74239092020-08-19 Postinfectious Autoimmune Hepatitis-Induced Liver Failure: A Consequence of Hepatitis A Virus Infection Subramanian, Sruthi Kapliyil Patel, Jigar M. Younes, Mamoun Nevah Rubin, Moises I. ACG Case Rep J Case Report Autoimmune hepatitis (AIH) is a chronic inflammatory immune-mediated hepatic pathology of unclear etiology. The mechanisms initiating and driving autoimmune inflammation of the liver and the loss of hepatic tolerance are still elusive. Several studies have documented the involvement of genetic factors and triggering agents such as toxic injury, treatment with immune-modifying drugs, or previous viral infections with perhaps strongest evidence for the hepatitis C virus. Rarely, AIH has been reported to develop after hepatitis A virus infection. We describe a case of de novo AIH in a patient with a history of recent hepatitis A virus infection. Wolters Kluwer 2020-08-11 /pmc/articles/PMC7423909/ /pubmed/32821769 http://dx.doi.org/10.14309/crj.0000000000000441 Text en © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Subramanian, Sruthi Kapliyil
Patel, Jigar M.
Younes, Mamoun
Nevah Rubin, Moises I.
Postinfectious Autoimmune Hepatitis-Induced Liver Failure: A Consequence of Hepatitis A Virus Infection
title Postinfectious Autoimmune Hepatitis-Induced Liver Failure: A Consequence of Hepatitis A Virus Infection
title_full Postinfectious Autoimmune Hepatitis-Induced Liver Failure: A Consequence of Hepatitis A Virus Infection
title_fullStr Postinfectious Autoimmune Hepatitis-Induced Liver Failure: A Consequence of Hepatitis A Virus Infection
title_full_unstemmed Postinfectious Autoimmune Hepatitis-Induced Liver Failure: A Consequence of Hepatitis A Virus Infection
title_short Postinfectious Autoimmune Hepatitis-Induced Liver Failure: A Consequence of Hepatitis A Virus Infection
title_sort postinfectious autoimmune hepatitis-induced liver failure: a consequence of hepatitis a virus infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423909/
https://www.ncbi.nlm.nih.gov/pubmed/32821769
http://dx.doi.org/10.14309/crj.0000000000000441
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