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The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation

BACKGROUND. Potential adverse effects, such as functional impairment of islets, render conventional immunosuppressive drugs unsuitable for use in islet transplantation. In addition, as a single therapy, they cannot prolong islet allograft survival. Here, we investigated the utility of the mitogen-ac...

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Detalles Bibliográficos
Autores principales:	Tada, Seiichiro, Anazawa, Takayuki, Shindo, Takero, Yamane, Kei, Inoguchi, Kenta, Fujimoto, Nanae, Nagai, Kazuyuki, Masui, Toshihiko, Okajima, Hideaki, Takaori, Kyoichi, Sumi, Shoichiro, Uemoto, Shinji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2020
Materias:	Pancreas and Islet Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423917/ https://www.ncbi.nlm.nih.gov/pubmed/32851124 http://dx.doi.org/10.1097/TXD.0000000000001045

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