Extract Derived From Black Rice Functions as a Photothermal Agent for Suppressing Tumor Growth and Metastasis

It remains a challenge to develop an effective therapeutic agent with low cost and good biocompatibility for cancer therapy. Based on its dark color, we hypothesized that, the extraction from black rice grains, denoted BRE, could serve as a photothermal conversion agent. The results showed that BRE...

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Detalles Bibliográficos
Autores principales: Teng, Muzhou, Zhou, Shuyi, Zhang, Rongjun, Zhang, Yu, Xu, Yang, Fu, Xuemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423996/
https://www.ncbi.nlm.nih.gov/pubmed/32850748
http://dx.doi.org/10.3389/fbioe.2020.00904
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author Teng, Muzhou
Zhou, Shuyi
Zhang, Rongjun
Zhang, Yu
Xu, Yang
Fu, Xuemei
author_facet Teng, Muzhou
Zhou, Shuyi
Zhang, Rongjun
Zhang, Yu
Xu, Yang
Fu, Xuemei
author_sort Teng, Muzhou
collection PubMed
description It remains a challenge to develop an effective therapeutic agent with low cost and good biocompatibility for cancer therapy. Based on its dark color, we hypothesized that, the extraction from black rice grains, denoted BRE, could serve as a photothermal conversion agent. The results showed that BRE confers a high photothermal conversion efficiency up to 54.13%. The combination of BRE and near infrared (NIR) treatment enables effective photothermal tumor ablation, and suppress tumor metastasis via inhibiting the epithelial-mesenchymal transition (EMT) pathway. In addition, BRE exhibits no obvious toxicity in vivo. Therefore, BRE could serve as a promising photothermal therapy agent with a low toxicity to treat cancer.
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spelling pubmed-74239962020-08-25 Extract Derived From Black Rice Functions as a Photothermal Agent for Suppressing Tumor Growth and Metastasis Teng, Muzhou Zhou, Shuyi Zhang, Rongjun Zhang, Yu Xu, Yang Fu, Xuemei Front Bioeng Biotechnol Bioengineering and Biotechnology It remains a challenge to develop an effective therapeutic agent with low cost and good biocompatibility for cancer therapy. Based on its dark color, we hypothesized that, the extraction from black rice grains, denoted BRE, could serve as a photothermal conversion agent. The results showed that BRE confers a high photothermal conversion efficiency up to 54.13%. The combination of BRE and near infrared (NIR) treatment enables effective photothermal tumor ablation, and suppress tumor metastasis via inhibiting the epithelial-mesenchymal transition (EMT) pathway. In addition, BRE exhibits no obvious toxicity in vivo. Therefore, BRE could serve as a promising photothermal therapy agent with a low toxicity to treat cancer. Frontiers Media S.A. 2020-08-06 /pmc/articles/PMC7423996/ /pubmed/32850748 http://dx.doi.org/10.3389/fbioe.2020.00904 Text en Copyright © 2020 Teng, Zhou, Zhang, Zhang, Xu and Fu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Teng, Muzhou
Zhou, Shuyi
Zhang, Rongjun
Zhang, Yu
Xu, Yang
Fu, Xuemei
Extract Derived From Black Rice Functions as a Photothermal Agent for Suppressing Tumor Growth and Metastasis
title Extract Derived From Black Rice Functions as a Photothermal Agent for Suppressing Tumor Growth and Metastasis
title_full Extract Derived From Black Rice Functions as a Photothermal Agent for Suppressing Tumor Growth and Metastasis
title_fullStr Extract Derived From Black Rice Functions as a Photothermal Agent for Suppressing Tumor Growth and Metastasis
title_full_unstemmed Extract Derived From Black Rice Functions as a Photothermal Agent for Suppressing Tumor Growth and Metastasis
title_short Extract Derived From Black Rice Functions as a Photothermal Agent for Suppressing Tumor Growth and Metastasis
title_sort extract derived from black rice functions as a photothermal agent for suppressing tumor growth and metastasis
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423996/
https://www.ncbi.nlm.nih.gov/pubmed/32850748
http://dx.doi.org/10.3389/fbioe.2020.00904
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