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Evaluation of the Mini-Mental State Examination and the Montreal Cognitive Assessment for Predicting Post-stroke Cognitive Impairment During the Acute Phase in Chinese Minor Stroke Patients

Objective: To assess the value of the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) during acute phase in predicting post-stroke cognitive impairment (PSCI) at 3–6 months. Methods: We prospectively recruited 229 patients who had suffered their first-ever ischemic...

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Autores principales: Zhu, Yueli, Zhao, Shuai, Fan, Ziqi, Li, Zheyu, He, Fan, Lin, Caixiu, Topatana, Win, Yan, Yaping, Liu, Zhirong, Chen, Yanxing, Zhang, Baorong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424073/
https://www.ncbi.nlm.nih.gov/pubmed/32848712
http://dx.doi.org/10.3389/fnagi.2020.00236
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author Zhu, Yueli
Zhao, Shuai
Fan, Ziqi
Li, Zheyu
He, Fan
Lin, Caixiu
Topatana, Win
Yan, Yaping
Liu, Zhirong
Chen, Yanxing
Zhang, Baorong
author_facet Zhu, Yueli
Zhao, Shuai
Fan, Ziqi
Li, Zheyu
He, Fan
Lin, Caixiu
Topatana, Win
Yan, Yaping
Liu, Zhirong
Chen, Yanxing
Zhang, Baorong
author_sort Zhu, Yueli
collection PubMed
description Objective: To assess the value of the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) during acute phase in predicting post-stroke cognitive impairment (PSCI) at 3–6 months. Methods: We prospectively recruited 229 patients who had suffered their first-ever ischemic stroke. PSCI was determined in 104 of these patients by a comprehensive neuropsychological battery performed at 3–6 months. Receiver operating characteristic (ROC) curve analysis was then performed to compare the discriminatory ability of the MMSE and MoCA. Also, we applied a decision tree generated by the classification and regression tree methodology. Results: In total, 66 patients had PSCI when evaluated 3–6 months after the onset of minor stroke. Logistic regression analysis revealed that education, body mass index (BMI), and baseline MoCA scores were independently associated with PSCI. ROC curve analysis showed that the ability to predict PSCI was similar when compared between baseline MoCA scores [area under curve (AUC), 0.821; 95% confidence interval (CI), 0.743–0.898] and baseline MMSE scores (AUC, 0.809; 95% CI, 0.725–0.892, P = 0.75). Both MMSE and MoCA exhibited similar predictive values at their optimal cut-off points (MMSE ≤27; sensitivity, 0.682; specificity, 0.816; MoCA ≤21; sensitivity, 0.636; specificity, 0.895). Classification and regression tree-derived analysis yielded an AUC of 0.823 (sensitivity, 0.803; specificity, 0.842). Conclusion: When applied within 2 weeks of stroke, the MMSE and MoCA are both useful and have similar predictive value for PSCI 3–6 months after the onset of minor stroke.
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spelling pubmed-74240732020-08-25 Evaluation of the Mini-Mental State Examination and the Montreal Cognitive Assessment for Predicting Post-stroke Cognitive Impairment During the Acute Phase in Chinese Minor Stroke Patients Zhu, Yueli Zhao, Shuai Fan, Ziqi Li, Zheyu He, Fan Lin, Caixiu Topatana, Win Yan, Yaping Liu, Zhirong Chen, Yanxing Zhang, Baorong Front Aging Neurosci Neuroscience Objective: To assess the value of the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) during acute phase in predicting post-stroke cognitive impairment (PSCI) at 3–6 months. Methods: We prospectively recruited 229 patients who had suffered their first-ever ischemic stroke. PSCI was determined in 104 of these patients by a comprehensive neuropsychological battery performed at 3–6 months. Receiver operating characteristic (ROC) curve analysis was then performed to compare the discriminatory ability of the MMSE and MoCA. Also, we applied a decision tree generated by the classification and regression tree methodology. Results: In total, 66 patients had PSCI when evaluated 3–6 months after the onset of minor stroke. Logistic regression analysis revealed that education, body mass index (BMI), and baseline MoCA scores were independently associated with PSCI. ROC curve analysis showed that the ability to predict PSCI was similar when compared between baseline MoCA scores [area under curve (AUC), 0.821; 95% confidence interval (CI), 0.743–0.898] and baseline MMSE scores (AUC, 0.809; 95% CI, 0.725–0.892, P = 0.75). Both MMSE and MoCA exhibited similar predictive values at their optimal cut-off points (MMSE ≤27; sensitivity, 0.682; specificity, 0.816; MoCA ≤21; sensitivity, 0.636; specificity, 0.895). Classification and regression tree-derived analysis yielded an AUC of 0.823 (sensitivity, 0.803; specificity, 0.842). Conclusion: When applied within 2 weeks of stroke, the MMSE and MoCA are both useful and have similar predictive value for PSCI 3–6 months after the onset of minor stroke. Frontiers Media S.A. 2020-08-06 /pmc/articles/PMC7424073/ /pubmed/32848712 http://dx.doi.org/10.3389/fnagi.2020.00236 Text en Copyright © 2020 Zhu, Zhao, Fan, Li, He, Lin, Topatana, Yan, Liu, Chen and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhu, Yueli
Zhao, Shuai
Fan, Ziqi
Li, Zheyu
He, Fan
Lin, Caixiu
Topatana, Win
Yan, Yaping
Liu, Zhirong
Chen, Yanxing
Zhang, Baorong
Evaluation of the Mini-Mental State Examination and the Montreal Cognitive Assessment for Predicting Post-stroke Cognitive Impairment During the Acute Phase in Chinese Minor Stroke Patients
title Evaluation of the Mini-Mental State Examination and the Montreal Cognitive Assessment for Predicting Post-stroke Cognitive Impairment During the Acute Phase in Chinese Minor Stroke Patients
title_full Evaluation of the Mini-Mental State Examination and the Montreal Cognitive Assessment for Predicting Post-stroke Cognitive Impairment During the Acute Phase in Chinese Minor Stroke Patients
title_fullStr Evaluation of the Mini-Mental State Examination and the Montreal Cognitive Assessment for Predicting Post-stroke Cognitive Impairment During the Acute Phase in Chinese Minor Stroke Patients
title_full_unstemmed Evaluation of the Mini-Mental State Examination and the Montreal Cognitive Assessment for Predicting Post-stroke Cognitive Impairment During the Acute Phase in Chinese Minor Stroke Patients
title_short Evaluation of the Mini-Mental State Examination and the Montreal Cognitive Assessment for Predicting Post-stroke Cognitive Impairment During the Acute Phase in Chinese Minor Stroke Patients
title_sort evaluation of the mini-mental state examination and the montreal cognitive assessment for predicting post-stroke cognitive impairment during the acute phase in chinese minor stroke patients
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424073/
https://www.ncbi.nlm.nih.gov/pubmed/32848712
http://dx.doi.org/10.3389/fnagi.2020.00236
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