The Cytokine Receptor IL-7Rα Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3(+) Treg Cells

IL-7 receptor signaling is essential for the generation and maintenance of conventional T cells. Immunosuppressive Foxp3(+) Treg cells, however, express uniquely low amounts of the IL-7-proprietary IL-7Rα so that they are impaired in IL-7 signaling. Because Treg cells depend on IL-2, the loss of IL-...

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Detalles Bibliográficos
Autores principales: Waickman, Adam T., Keller, Hilary R., Kim, Tae-Hyoun, Luckey, Megan A., Tai, Xuguang, Hong, Changwan, Molina-París, Carmen, Walsh, Scott T.R., Park, Jung-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424196/
https://www.ncbi.nlm.nih.gov/pubmed/32791329
http://dx.doi.org/10.1016/j.isci.2020.101421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424196/
https://www.ncbi.nlm.nih.gov/pubmed/32791329
http://dx.doi.org/10.1016/j.isci.2020.101421

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