Purification of Human CD34(+)CD90(+) HSCs Reduces Target Cell Population and Improves Lentiviral Transduction for Gene Therapy

Hematopoietic stem cell (HSC) gene therapy has the potential to cure many genetic, malignant, and infectious diseases. We have shown in a nonhuman primate gene therapy and transplantation model that the CD34(+)CD90(+) cell fraction was exclusively responsible for multilineage engraftment and hematop...

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Detalles Bibliográficos
Autores principales: Radtke, Stefan, Pande, Dnyanada, Cui, Margaret, Perez, Anai M., Chan, Yan-Yi, Enstrom, Mark, Schmuck, Stefanie, Berger, Andrew, Eunson, Tom, Adair, Jennifer E., Kiem, Hans-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424231/
https://www.ncbi.nlm.nih.gov/pubmed/32802914
http://dx.doi.org/10.1016/j.omtm.2020.07.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424231/
https://www.ncbi.nlm.nih.gov/pubmed/32802914
http://dx.doi.org/10.1016/j.omtm.2020.07.010

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