Cargando…
A registry for patients with chronic hypoparathyroidism in Russian adults
Hypoparathyroidism and pseudohypoparathyroidism are rare endocrine disorders, characterized by low serum calcium due to inappropriate parathyroid hormone (PTH) levels or resistance to its action. There is little epidemiological information regarding chronic hypoparathyroidism in Russia. This study a...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424359/ https://www.ncbi.nlm.nih.gov/pubmed/32580149 http://dx.doi.org/10.1530/EC-20-0219 |
_version_ | 1783570323652739072 |
---|---|
author | Gronskaia, Sofya Melnichenko, Galina Rozhinskaya, Liudmila Grebennikova, Tatiana Mamedova, Elizaveta Pigarova, Ekaterina Przhialkovskaya, Elena Dzeranova, Larisa Dedov, Ivan Fadeyev, Valentin Brandi, Maria Luisa Belaya, Zhanna |
author_facet | Gronskaia, Sofya Melnichenko, Galina Rozhinskaya, Liudmila Grebennikova, Tatiana Mamedova, Elizaveta Pigarova, Ekaterina Przhialkovskaya, Elena Dzeranova, Larisa Dedov, Ivan Fadeyev, Valentin Brandi, Maria Luisa Belaya, Zhanna |
author_sort | Gronskaia, Sofya |
collection | PubMed |
description | Hypoparathyroidism and pseudohypoparathyroidism are rare endocrine disorders, characterized by low serum calcium due to inappropriate parathyroid hormone (PTH) levels or resistance to its action. There is little epidemiological information regarding chronic hypoparathyroidism in Russia. This study aims to build a registry database of Russian patients with chronic hypoparathyroidism who were referred for hospital treatment in order to conduct initial analysis of clinical presentations and hospital management. The Italian registry model was taken to be able to integrate our data in the future. Two hundred patients with hypoparathyroidism (n = 194) and pseudohypoparathyroidism (n = 6) were enrolled over 2 years (2017–2019). The most frequent cause of hypoparathyroidism was neck surgery (82.5%, mostly females), followed by idiopathic hypoparathyroidism (10%), syndromic forms of genetic hypoparathyroidism (4.5%) and forms of defective PTH action (3%). Calcium supplements and alfacalcidol were prescribed in most cases. However, a minority of patients (n = 6) needed to receive teriparatide as the only way to maintain calcium levels and to prevent symptoms of hypocalcemia. Consequently, substitution treatment with parathyroid hormone should be available in certain cases of hypoparathyroidism. This database will be useful to estimate the potential requirement for recombinant PTH in Russia and standards for clinical and therapeutic approaches. |
format | Online Article Text |
id | pubmed-7424359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-74243592020-08-17 A registry for patients with chronic hypoparathyroidism in Russian adults Gronskaia, Sofya Melnichenko, Galina Rozhinskaya, Liudmila Grebennikova, Tatiana Mamedova, Elizaveta Pigarova, Ekaterina Przhialkovskaya, Elena Dzeranova, Larisa Dedov, Ivan Fadeyev, Valentin Brandi, Maria Luisa Belaya, Zhanna Endocr Connect Research Hypoparathyroidism and pseudohypoparathyroidism are rare endocrine disorders, characterized by low serum calcium due to inappropriate parathyroid hormone (PTH) levels or resistance to its action. There is little epidemiological information regarding chronic hypoparathyroidism in Russia. This study aims to build a registry database of Russian patients with chronic hypoparathyroidism who were referred for hospital treatment in order to conduct initial analysis of clinical presentations and hospital management. The Italian registry model was taken to be able to integrate our data in the future. Two hundred patients with hypoparathyroidism (n = 194) and pseudohypoparathyroidism (n = 6) were enrolled over 2 years (2017–2019). The most frequent cause of hypoparathyroidism was neck surgery (82.5%, mostly females), followed by idiopathic hypoparathyroidism (10%), syndromic forms of genetic hypoparathyroidism (4.5%) and forms of defective PTH action (3%). Calcium supplements and alfacalcidol were prescribed in most cases. However, a minority of patients (n = 6) needed to receive teriparatide as the only way to maintain calcium levels and to prevent symptoms of hypocalcemia. Consequently, substitution treatment with parathyroid hormone should be available in certain cases of hypoparathyroidism. This database will be useful to estimate the potential requirement for recombinant PTH in Russia and standards for clinical and therapeutic approaches. Bioscientifica Ltd 2020-06-04 /pmc/articles/PMC7424359/ /pubmed/32580149 http://dx.doi.org/10.1530/EC-20-0219 Text en © 2020 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Research Gronskaia, Sofya Melnichenko, Galina Rozhinskaya, Liudmila Grebennikova, Tatiana Mamedova, Elizaveta Pigarova, Ekaterina Przhialkovskaya, Elena Dzeranova, Larisa Dedov, Ivan Fadeyev, Valentin Brandi, Maria Luisa Belaya, Zhanna A registry for patients with chronic hypoparathyroidism in Russian adults |
title | A registry for patients with chronic hypoparathyroidism in Russian adults |
title_full | A registry for patients with chronic hypoparathyroidism in Russian adults |
title_fullStr | A registry for patients with chronic hypoparathyroidism in Russian adults |
title_full_unstemmed | A registry for patients with chronic hypoparathyroidism in Russian adults |
title_short | A registry for patients with chronic hypoparathyroidism in Russian adults |
title_sort | registry for patients with chronic hypoparathyroidism in russian adults |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424359/ https://www.ncbi.nlm.nih.gov/pubmed/32580149 http://dx.doi.org/10.1530/EC-20-0219 |
work_keys_str_mv | AT gronskaiasofya aregistryforpatientswithchronichypoparathyroidisminrussianadults AT melnichenkogalina aregistryforpatientswithchronichypoparathyroidisminrussianadults AT rozhinskayaliudmila aregistryforpatientswithchronichypoparathyroidisminrussianadults AT grebennikovatatiana aregistryforpatientswithchronichypoparathyroidisminrussianadults AT mamedovaelizaveta aregistryforpatientswithchronichypoparathyroidisminrussianadults AT pigarovaekaterina aregistryforpatientswithchronichypoparathyroidisminrussianadults AT przhialkovskayaelena aregistryforpatientswithchronichypoparathyroidisminrussianadults AT dzeranovalarisa aregistryforpatientswithchronichypoparathyroidisminrussianadults AT dedovivan aregistryforpatientswithchronichypoparathyroidisminrussianadults AT fadeyevvalentin aregistryforpatientswithchronichypoparathyroidisminrussianadults AT brandimarialuisa aregistryforpatientswithchronichypoparathyroidisminrussianadults AT belayazhanna aregistryforpatientswithchronichypoparathyroidisminrussianadults AT gronskaiasofya registryforpatientswithchronichypoparathyroidisminrussianadults AT melnichenkogalina registryforpatientswithchronichypoparathyroidisminrussianadults AT rozhinskayaliudmila registryforpatientswithchronichypoparathyroidisminrussianadults AT grebennikovatatiana registryforpatientswithchronichypoparathyroidisminrussianadults AT mamedovaelizaveta registryforpatientswithchronichypoparathyroidisminrussianadults AT pigarovaekaterina registryforpatientswithchronichypoparathyroidisminrussianadults AT przhialkovskayaelena registryforpatientswithchronichypoparathyroidisminrussianadults AT dzeranovalarisa registryforpatientswithchronichypoparathyroidisminrussianadults AT dedovivan registryforpatientswithchronichypoparathyroidisminrussianadults AT fadeyevvalentin registryforpatientswithchronichypoparathyroidisminrussianadults AT brandimarialuisa registryforpatientswithchronichypoparathyroidisminrussianadults AT belayazhanna registryforpatientswithchronichypoparathyroidisminrussianadults |