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A registry for patients with chronic hypoparathyroidism in Russian adults

Hypoparathyroidism and pseudohypoparathyroidism are rare endocrine disorders, characterized by low serum calcium due to inappropriate parathyroid hormone (PTH) levels or resistance to its action. There is little epidemiological information regarding chronic hypoparathyroidism in Russia. This study a...

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Autores principales: Gronskaia, Sofya, Melnichenko, Galina, Rozhinskaya, Liudmila, Grebennikova, Tatiana, Mamedova, Elizaveta, Pigarova, Ekaterina, Przhialkovskaya, Elena, Dzeranova, Larisa, Dedov, Ivan, Fadeyev, Valentin, Brandi, Maria Luisa, Belaya, Zhanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424359/
https://www.ncbi.nlm.nih.gov/pubmed/32580149
http://dx.doi.org/10.1530/EC-20-0219
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author Gronskaia, Sofya
Melnichenko, Galina
Rozhinskaya, Liudmila
Grebennikova, Tatiana
Mamedova, Elizaveta
Pigarova, Ekaterina
Przhialkovskaya, Elena
Dzeranova, Larisa
Dedov, Ivan
Fadeyev, Valentin
Brandi, Maria Luisa
Belaya, Zhanna
author_facet Gronskaia, Sofya
Melnichenko, Galina
Rozhinskaya, Liudmila
Grebennikova, Tatiana
Mamedova, Elizaveta
Pigarova, Ekaterina
Przhialkovskaya, Elena
Dzeranova, Larisa
Dedov, Ivan
Fadeyev, Valentin
Brandi, Maria Luisa
Belaya, Zhanna
author_sort Gronskaia, Sofya
collection PubMed
description Hypoparathyroidism and pseudohypoparathyroidism are rare endocrine disorders, characterized by low serum calcium due to inappropriate parathyroid hormone (PTH) levels or resistance to its action. There is little epidemiological information regarding chronic hypoparathyroidism in Russia. This study aims to build a registry database of Russian patients with chronic hypoparathyroidism who were referred for hospital treatment in order to conduct initial analysis of clinical presentations and hospital management. The Italian registry model was taken to be able to integrate our data in the future. Two hundred patients with hypoparathyroidism (n = 194) and pseudohypoparathyroidism (n = 6) were enrolled over 2 years (2017–2019). The most frequent cause of hypoparathyroidism was neck surgery (82.5%, mostly females), followed by idiopathic hypoparathyroidism (10%), syndromic forms of genetic hypoparathyroidism (4.5%) and forms of defective PTH action (3%). Calcium supplements and alfacalcidol were prescribed in most cases. However, a minority of patients (n = 6) needed to receive teriparatide as the only way to maintain calcium levels and to prevent symptoms of hypocalcemia. Consequently, substitution treatment with parathyroid hormone should be available in certain cases of hypoparathyroidism. This database will be useful to estimate the potential requirement for recombinant PTH in Russia and standards for clinical and therapeutic approaches.
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spelling pubmed-74243592020-08-17 A registry for patients with chronic hypoparathyroidism in Russian adults Gronskaia, Sofya Melnichenko, Galina Rozhinskaya, Liudmila Grebennikova, Tatiana Mamedova, Elizaveta Pigarova, Ekaterina Przhialkovskaya, Elena Dzeranova, Larisa Dedov, Ivan Fadeyev, Valentin Brandi, Maria Luisa Belaya, Zhanna Endocr Connect Research Hypoparathyroidism and pseudohypoparathyroidism are rare endocrine disorders, characterized by low serum calcium due to inappropriate parathyroid hormone (PTH) levels or resistance to its action. There is little epidemiological information regarding chronic hypoparathyroidism in Russia. This study aims to build a registry database of Russian patients with chronic hypoparathyroidism who were referred for hospital treatment in order to conduct initial analysis of clinical presentations and hospital management. The Italian registry model was taken to be able to integrate our data in the future. Two hundred patients with hypoparathyroidism (n = 194) and pseudohypoparathyroidism (n = 6) were enrolled over 2 years (2017–2019). The most frequent cause of hypoparathyroidism was neck surgery (82.5%, mostly females), followed by idiopathic hypoparathyroidism (10%), syndromic forms of genetic hypoparathyroidism (4.5%) and forms of defective PTH action (3%). Calcium supplements and alfacalcidol were prescribed in most cases. However, a minority of patients (n = 6) needed to receive teriparatide as the only way to maintain calcium levels and to prevent symptoms of hypocalcemia. Consequently, substitution treatment with parathyroid hormone should be available in certain cases of hypoparathyroidism. This database will be useful to estimate the potential requirement for recombinant PTH in Russia and standards for clinical and therapeutic approaches. Bioscientifica Ltd 2020-06-04 /pmc/articles/PMC7424359/ /pubmed/32580149 http://dx.doi.org/10.1530/EC-20-0219 Text en © 2020 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Research
Gronskaia, Sofya
Melnichenko, Galina
Rozhinskaya, Liudmila
Grebennikova, Tatiana
Mamedova, Elizaveta
Pigarova, Ekaterina
Przhialkovskaya, Elena
Dzeranova, Larisa
Dedov, Ivan
Fadeyev, Valentin
Brandi, Maria Luisa
Belaya, Zhanna
A registry for patients with chronic hypoparathyroidism in Russian adults
title A registry for patients with chronic hypoparathyroidism in Russian adults
title_full A registry for patients with chronic hypoparathyroidism in Russian adults
title_fullStr A registry for patients with chronic hypoparathyroidism in Russian adults
title_full_unstemmed A registry for patients with chronic hypoparathyroidism in Russian adults
title_short A registry for patients with chronic hypoparathyroidism in Russian adults
title_sort registry for patients with chronic hypoparathyroidism in russian adults
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424359/
https://www.ncbi.nlm.nih.gov/pubmed/32580149
http://dx.doi.org/10.1530/EC-20-0219
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