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Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression: A Randomized Clinical Trial

IMPORTANCE: A single subanesthetic dose of ketamine produces an antidepressant response in patients with major depressive disorder (MDD) within hours, but the mechanism of antidepressant effect is uncertain. OBJECTIVE: To evaluate whether ketamine dose and brain glutamate and glutamine (Glx) and γ-a...

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Detalles Bibliográficos
Autores principales:	Milak, Matthew S., Rashid, Rain, Dong, Zhengchao, Kegeles, Lawrence S., Grunebaum, Michael F., Ogden, R. Todd, Lin, Xuejing, Mulhern, Stephanie T., Suckow, Raymond F., Cooper, Thomas B., Keilp, John G., Mao, Xiangling, Shungu, Dikoma C., Mann, J. John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Medical Association 2020
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424409/ https://www.ncbi.nlm.nih.gov/pubmed/32785636 http://dx.doi.org/10.1001/jamanetworkopen.2020.13211

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