The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa....

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Autores principales: Tanase, Daniela Maria, Gosav, Evelina Maria, Costea, Claudia Florida, Ciocoiu, Manuela, Lacatusu, Cristina Mihaela, Maranduca, Minela Aida, Ouatu, Anca, Floria, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424491/
https://www.ncbi.nlm.nih.gov/pubmed/32832560
http://dx.doi.org/10.1155/2020/3920196
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author Tanase, Daniela Maria
Gosav, Evelina Maria
Costea, Claudia Florida
Ciocoiu, Manuela
Lacatusu, Cristina Mihaela
Maranduca, Minela Aida
Ouatu, Anca
Floria, Mariana
author_facet Tanase, Daniela Maria
Gosav, Evelina Maria
Costea, Claudia Florida
Ciocoiu, Manuela
Lacatusu, Cristina Mihaela
Maranduca, Minela Aida
Ouatu, Anca
Floria, Mariana
author_sort Tanase, Daniela Maria
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.
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spelling pubmed-74244912020-08-20 The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD) Tanase, Daniela Maria Gosav, Evelina Maria Costea, Claudia Florida Ciocoiu, Manuela Lacatusu, Cristina Mihaela Maranduca, Minela Aida Ouatu, Anca Floria, Mariana J Diabetes Res Review Article Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets. Hindawi 2020-07-31 /pmc/articles/PMC7424491/ /pubmed/32832560 http://dx.doi.org/10.1155/2020/3920196 Text en Copyright © 2020 Daniela Maria Tanase et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tanase, Daniela Maria
Gosav, Evelina Maria
Costea, Claudia Florida
Ciocoiu, Manuela
Lacatusu, Cristina Mihaela
Maranduca, Minela Aida
Ouatu, Anca
Floria, Mariana
The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)
title The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)
title_full The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)
title_fullStr The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)
title_full_unstemmed The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)
title_short The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)
title_sort intricate relationship between type 2 diabetes mellitus (t2dm), insulin resistance (ir), and nonalcoholic fatty liver disease (nafld)
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424491/
https://www.ncbi.nlm.nih.gov/pubmed/32832560
http://dx.doi.org/10.1155/2020/3920196
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