Profound Functional Suppression of Tumor-Infiltrating T-Cells in Ovarian Cancer Patients Can Be Reversed Using PD-1-Blocking Antibodies or DARPin® Proteins

PD-1/PD-L1 blockade has revolutionized the field of immunooncology. Despite the relative success, the response rate to anti-PD-1 therapy requires further improvements. Our aim was to explore the enhancement of T-cell function by using novel PD-1-blocking proteins and compare with clinically approved...

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Detalles Bibliográficos
Autores principales: Foord, Emelie, Klynning, Charlotte, Schoutrop, Esther, Förster, Judith M., Krieg, Jennifer, Mörtberg, Anette, Müller, Mischa R., Herzog, Christel, Schiegg, Dieter, Villemagne, Denis, Fiedler, Ulrike, Snell, Dan, Kebble, Benjamin, Mattsson, Jonas, Levitsky, Victor, Uhlin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424497/
https://www.ncbi.nlm.nih.gov/pubmed/32832572
http://dx.doi.org/10.1155/2020/7375947

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