DUX4 expressing immortalized FSHD lymphoblastoid cells express genes elevated in FSHD muscle biopsies, correlating with the early stages of inflammation

Facioscapulohumeral muscular dystrophy (FSHD) is an incurable disorder linked to ectopic expression of DUX4. However, DUX4 is notoriously difficult to detect in FSHD muscle cells, while DUX4 target gene expression is an inconsistent biomarker for FSHD skeletal muscle biopsies, displaying efficacy on...

Descripción completa

Detalles Bibliográficos
Autores principales: Banerji, Christopher R S, Panamarova, Maryna, Zammit, Peter S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424723/
https://www.ncbi.nlm.nih.gov/pubmed/32242220
http://dx.doi.org/10.1093/hmg/ddaa053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424723/
https://www.ncbi.nlm.nih.gov/pubmed/32242220
http://dx.doi.org/10.1093/hmg/ddaa053

Ejemplares similares