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Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus
Albumin has an oxidized form, known as non-mercaptalbumin (HNA), which reflects systemic oxidative stress. The association between serum HNA levels and diabetic complications are yet to be reported. In this cross-sectional study, we investigated 164 diabetic subjects to assess the correlation betwee...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424782/ https://www.ncbi.nlm.nih.gov/pubmed/32812907 http://dx.doi.org/10.1016/j.metop.2020.100032 |
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author | Kobayashi, Yuka Suzuki, Ryo Yasukawa, Keiko Oba, Koji Yamauchi, Toshimasa Yatomi, Yutaka Kadowaki, Takashi |
author_facet | Kobayashi, Yuka Suzuki, Ryo Yasukawa, Keiko Oba, Koji Yamauchi, Toshimasa Yatomi, Yutaka Kadowaki, Takashi |
author_sort | Kobayashi, Yuka |
collection | PubMed |
description | Albumin has an oxidized form, known as non-mercaptalbumin (HNA), which reflects systemic oxidative stress. The association between serum HNA levels and diabetic complications are yet to be reported. In this cross-sectional study, we investigated 164 diabetic subjects to assess the correlation between HNA% (the proportion in the total albumin) and various clinical parameters. HNA% was significantly associated with the severity of multiple complications including neuropathy (23.3 ± 4.1% vs 26.2 ± 5.1%) and nephropathy (24.1 ± 3.9%, 24.6 ± 4.2%, 28.5 ± 6.1%, 31.3 ± 5.7%, 37.8 ± 2.9%, stage 1/2/3/4/5, respectively). These findings highlight the universal importance of oxidative stress, indicating HNA% potential as a versatile marker of the severity of diabetic complications. |
format | Online Article Text |
id | pubmed-7424782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74247822020-08-17 Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus Kobayashi, Yuka Suzuki, Ryo Yasukawa, Keiko Oba, Koji Yamauchi, Toshimasa Yatomi, Yutaka Kadowaki, Takashi Metabol Open Original Research Paper Albumin has an oxidized form, known as non-mercaptalbumin (HNA), which reflects systemic oxidative stress. The association between serum HNA levels and diabetic complications are yet to be reported. In this cross-sectional study, we investigated 164 diabetic subjects to assess the correlation between HNA% (the proportion in the total albumin) and various clinical parameters. HNA% was significantly associated with the severity of multiple complications including neuropathy (23.3 ± 4.1% vs 26.2 ± 5.1%) and nephropathy (24.1 ± 3.9%, 24.6 ± 4.2%, 28.5 ± 6.1%, 31.3 ± 5.7%, 37.8 ± 2.9%, stage 1/2/3/4/5, respectively). These findings highlight the universal importance of oxidative stress, indicating HNA% potential as a versatile marker of the severity of diabetic complications. Elsevier 2020-03-14 /pmc/articles/PMC7424782/ /pubmed/32812907 http://dx.doi.org/10.1016/j.metop.2020.100032 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Paper Kobayashi, Yuka Suzuki, Ryo Yasukawa, Keiko Oba, Koji Yamauchi, Toshimasa Yatomi, Yutaka Kadowaki, Takashi Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus |
title | Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus |
title_full | Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus |
title_fullStr | Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus |
title_full_unstemmed | Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus |
title_short | Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus |
title_sort | oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus |
topic | Original Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424782/ https://www.ncbi.nlm.nih.gov/pubmed/32812907 http://dx.doi.org/10.1016/j.metop.2020.100032 |
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