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Obesity-induced inflammation and insulin resistance: A mini-review on T-cells
Excessive lipid accumulation in an obese state is linked with activation and release of detrimental cytokines and chemokines that promote metabolic dysregulation. In fact, emerging experimental evidence shows that abnormal modulation of T-cells in an obese state correlates with the development and p...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424835/ https://www.ncbi.nlm.nih.gov/pubmed/32812921 http://dx.doi.org/10.1016/j.metop.2019.100015 |
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author | Nyambuya, Tawanda Maurice Dludla, Phiwayinkosi Vusi Mxinwa, Vuyolwethu Nkambule, Bongani Brian |
author_facet | Nyambuya, Tawanda Maurice Dludla, Phiwayinkosi Vusi Mxinwa, Vuyolwethu Nkambule, Bongani Brian |
author_sort | Nyambuya, Tawanda Maurice |
collection | PubMed |
description | Excessive lipid accumulation in an obese state is linked with activation and release of detrimental cytokines and chemokines that promote metabolic dysregulation. In fact, emerging experimental evidence shows that abnormal modulation of T-cells in an obese state correlates with the development and progression of insulin resistance. Importantly, the evolving concept linking insulin resistance with impaired immunological mechanisms such as T-cell responses provides new prospects for understanding the role of inflammation in moderating metabolic complications. |
format | Online Article Text |
id | pubmed-7424835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74248352020-08-17 Obesity-induced inflammation and insulin resistance: A mini-review on T-cells Nyambuya, Tawanda Maurice Dludla, Phiwayinkosi Vusi Mxinwa, Vuyolwethu Nkambule, Bongani Brian Metabol Open Original Research Paper Excessive lipid accumulation in an obese state is linked with activation and release of detrimental cytokines and chemokines that promote metabolic dysregulation. In fact, emerging experimental evidence shows that abnormal modulation of T-cells in an obese state correlates with the development and progression of insulin resistance. Importantly, the evolving concept linking insulin resistance with impaired immunological mechanisms such as T-cell responses provides new prospects for understanding the role of inflammation in moderating metabolic complications. Elsevier 2019-08-10 /pmc/articles/PMC7424835/ /pubmed/32812921 http://dx.doi.org/10.1016/j.metop.2019.100015 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Paper Nyambuya, Tawanda Maurice Dludla, Phiwayinkosi Vusi Mxinwa, Vuyolwethu Nkambule, Bongani Brian Obesity-induced inflammation and insulin resistance: A mini-review on T-cells |
title | Obesity-induced inflammation and insulin resistance: A mini-review on T-cells |
title_full | Obesity-induced inflammation and insulin resistance: A mini-review on T-cells |
title_fullStr | Obesity-induced inflammation and insulin resistance: A mini-review on T-cells |
title_full_unstemmed | Obesity-induced inflammation and insulin resistance: A mini-review on T-cells |
title_short | Obesity-induced inflammation and insulin resistance: A mini-review on T-cells |
title_sort | obesity-induced inflammation and insulin resistance: a mini-review on t-cells |
topic | Original Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424835/ https://www.ncbi.nlm.nih.gov/pubmed/32812921 http://dx.doi.org/10.1016/j.metop.2019.100015 |
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