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Obesity-induced inflammation and insulin resistance: A mini-review on T-cells

Excessive lipid accumulation in an obese state is linked with activation and release of detrimental cytokines and chemokines that promote metabolic dysregulation. In fact, emerging experimental evidence shows that abnormal modulation of T-cells in an obese state correlates with the development and p...

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Autores principales: Nyambuya, Tawanda Maurice, Dludla, Phiwayinkosi Vusi, Mxinwa, Vuyolwethu, Nkambule, Bongani Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424835/
https://www.ncbi.nlm.nih.gov/pubmed/32812921
http://dx.doi.org/10.1016/j.metop.2019.100015
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author Nyambuya, Tawanda Maurice
Dludla, Phiwayinkosi Vusi
Mxinwa, Vuyolwethu
Nkambule, Bongani Brian
author_facet Nyambuya, Tawanda Maurice
Dludla, Phiwayinkosi Vusi
Mxinwa, Vuyolwethu
Nkambule, Bongani Brian
author_sort Nyambuya, Tawanda Maurice
collection PubMed
description Excessive lipid accumulation in an obese state is linked with activation and release of detrimental cytokines and chemokines that promote metabolic dysregulation. In fact, emerging experimental evidence shows that abnormal modulation of T-cells in an obese state correlates with the development and progression of insulin resistance. Importantly, the evolving concept linking insulin resistance with impaired immunological mechanisms such as T-cell responses provides new prospects for understanding the role of inflammation in moderating metabolic complications.
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spelling pubmed-74248352020-08-17 Obesity-induced inflammation and insulin resistance: A mini-review on T-cells Nyambuya, Tawanda Maurice Dludla, Phiwayinkosi Vusi Mxinwa, Vuyolwethu Nkambule, Bongani Brian Metabol Open Original Research Paper Excessive lipid accumulation in an obese state is linked with activation and release of detrimental cytokines and chemokines that promote metabolic dysregulation. In fact, emerging experimental evidence shows that abnormal modulation of T-cells in an obese state correlates with the development and progression of insulin resistance. Importantly, the evolving concept linking insulin resistance with impaired immunological mechanisms such as T-cell responses provides new prospects for understanding the role of inflammation in moderating metabolic complications. Elsevier 2019-08-10 /pmc/articles/PMC7424835/ /pubmed/32812921 http://dx.doi.org/10.1016/j.metop.2019.100015 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Paper
Nyambuya, Tawanda Maurice
Dludla, Phiwayinkosi Vusi
Mxinwa, Vuyolwethu
Nkambule, Bongani Brian
Obesity-induced inflammation and insulin resistance: A mini-review on T-cells
title Obesity-induced inflammation and insulin resistance: A mini-review on T-cells
title_full Obesity-induced inflammation and insulin resistance: A mini-review on T-cells
title_fullStr Obesity-induced inflammation and insulin resistance: A mini-review on T-cells
title_full_unstemmed Obesity-induced inflammation and insulin resistance: A mini-review on T-cells
title_short Obesity-induced inflammation and insulin resistance: A mini-review on T-cells
title_sort obesity-induced inflammation and insulin resistance: a mini-review on t-cells
topic Original Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424835/
https://www.ncbi.nlm.nih.gov/pubmed/32812921
http://dx.doi.org/10.1016/j.metop.2019.100015
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