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Modeling and analysis of Hi-C data by HiSIF identifies characteristic promoter-distal loops
Current computational methods on Hi-C analysis focused on identifying Mb-size domains often failed to unveil the underlying functional and mechanistic relationship of chromatin structure and gene regulation. We developed a novel computational method HiSIF to identify genome-wide interacting loci. We...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425017/ https://www.ncbi.nlm.nih.gov/pubmed/32787954 http://dx.doi.org/10.1186/s13073-020-00769-8 |