Cargando…

Exceptional response to nivolumab of a heavily pre-treated patient with metastatic renal-cell cancer: from a case report to molecular investigation and future perspectives

Immunotherapy may result in long-lasting exceptional clinical responses, the molecular background of which is inadequately understood. Here, we present the case of a 63-year-old patient with a past medical history of renal cancer who relapsed many years later. Several treatment lines were administer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dimitrakopoulos, Foteinos-Ioannis D., Kourea, Eleni, Nasioulas, George, Papadopoulou, Eirini, Nikolakopoulos, Achilles, Spyropoulou, Despoina, Kottorou, Anastasia, Karatzas, Andreas, Kalofonos, Haralabos P., Koutras, Angelos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425249/ https://www.ncbi.nlm.nih.gov/pubmed/32849917 http://dx.doi.org/10.1177/1758835920946152

Ejemplares similares

PIOS (Patras Immunotherapy Score) Score Is Associated with Best Overall Response, Progression-Free Survival, and Post-Immunotherapy Overall Survival in Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC) Treated with Anti-Program Cell Death-1 (PD-1) Inhibitors
por: Dimitrakopoulos, Foteinos-Ioannis, et al.
Publicado: (2020)

Small Extracellular Vesicles (sEVs) Biogenesis Molecular Players Are Associated with Clinical Outcome of Colorectal Cancer Patients
por: Kottorou, Anastasia, et al.
Publicado: (2023)

NF-κB2 and RELB offer prognostic information in colorectal cancer and NFKB2 rs7897947 represents a genetic risk factor for disease development
por: Antonacopoulou, Anna, et al.
Publicado: (2020)

Genetic Variations of CD40 and LTβR Genes Are Associated With Increased Susceptibility and Clinical Outcome of Non-Small-Cell Carcinoma Patients
por: Dimitrakopoulos, Foteinos-Ioannis D., et al.
Publicado: (2021)

Expression of Immune System-Related Membrane Receptors CD40, RANK, BAFFR and LTβR is Associated with Clinical Outcome of Operated Non-Small-Cell Lung Cancer Patients
por: Dimitrakopoulos, Foteinos-Ioannis D., et al.
Publicado: (2019)

Differentially Methylated Ultra-Conserved Regions Uc160 and Uc283 in Adenomas and Adenocarcinomas Are Associated with Overall Survival of Colorectal Cancer Patients
por: Kottorou, Anastasia E., et al.
Publicado: (2020)

Prognostic Value of Circulating Tumor DNA (ctDNA) in Oncogene-Driven NSCLC: Current Knowledge and Future Perspectives
por: Zografos, Eleni, et al.
Publicado: (2022)

NF-kB2 Genetic Variations are Significantly Associated with Non-Small Cell Lung Cancer Risk and Overall Survival
por: Dimitrakopoulos, Foteinos-Ioannis D., et al.
Publicado: (2018)

Expression Of Intracellular Components of the NF-κB Alternative Pathway (NF-κB2, RelB, NIK and Bcl3) is Associated With Clinical Outcome of NSCLC Patients
por: Dimitrakopoulos, Foteinos-Ioannis D., et al.
Publicado: (2019)

Non-coding RNAs in cancer-associated cachexia: clinical implications and future perspectives
por: Kottorou, Anastasia, et al.
Publicado: (2021)

Validation of Patras Immunotherapy Score model for prediction and prognosis of patients with advanced NSCLC treated with nivolumab or pembrolizumab: results from a European multicentre study
por: Dimitrakopoulos, Foteinos-Ioannis, et al.
Publicado: (2022)

Early-Stage Breast Cancer in the Elderly: Confronting an Old Clinical Problem
por: Dimitrakopoulos, Fotinos-Ioannis D., et al.
Publicado: (2015)

Radical Tumor Denervation Activates Potent Local and Global Cancer Treatment
por: Mitsou, John D., et al.
Publicado: (2023)

Deregulation of methylation of transcribed-ultra conserved regions in colorectal cancer and their value for detection of adenomas and adenocarcinomas
por: Kottorou, Anastasia E., et al.
Publicado: (2018)

The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
por: Antonacopoulou, Anna G., et al.
Publicado: (2010)

Identification of a seasonal pattern to brain metastases
por: Sakellakis, Minas, et al.
Publicado: (2016)

Adhesion strength and anti-tumor agents regulate vinculin of breast cancer cells
por: Metsiou, Despoina Nektaria, et al.
Publicado: (2022)

The Exposure of Breast Cancer Cells to Fulvestrant and Tamoxifen Modulates Cell Migration Differently
por: Lymperatou, Dionysia, et al.
Publicado: (2013)

Clinical Significance of Major Angiogenesis-Related Effectors in Patients with Metastatic Breast Cancer Treated with Trastuzumab-Based Regimens
por: Kourea, Helen P., et al.
Publicado: (2022)

Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome
por: Giannakopoulos, Marios P, et al.
Publicado: (2016)

Genetic Variation in the Vascular Endothelial Growth Factor (VEGFA) Gene at rs13207351 Is Associated with Overall Survival of Patients with Head and Neck Cancer
por: Dimitrakopoulos, Foteinos-Ioannis, et al.
Publicado: (2021)

Phenotypic Characterization of Circulating Tumor Cells Isolated from Non-Small and Small Cell Lung Cancer Patients
por: Roumeliotou, Argyro, et al.
Publicado: (2022)

Antiproliferative effect of exemestane in lung cancer cells
por: Koutras, Angelos, et al.
Publicado: (2009)

Immune checkpoint inhibitor-induced musculoskeletal manifestations. A multicentre prospective study
por: Daoussis, Dimitrios, et al.
Publicado: (2020)

Statins and risk of breast cancer recurrence
por: Sakellakis, Minas, et al.
Publicado: (2016)

RANK-C Expression Sensitizes ER-Negative, EGFR-Positive Breast Cancer Cells to EGFR-Tyrosine Kinase Inhibitors (TKIs)
por: Sirinian, Chaido, et al.
Publicado: (2021)

An exceptional response to nivolumab in relapsed and refractory malignant mesothelioma
por: Talreja, Vikas T., et al.
Publicado: (2019)

KRAS, NRAS and BRAF mutations in Greek and Romanian patients with colorectal cancer: a cohort study
por: Negru, Serban, et al.
Publicado: (2014)

Pharmacogenetics in Model-Based Optimization of Bevacizumab Therapy for Metastatic Colorectal Cancer
por: Papachristos, Apostolos, et al.
Publicado: (2020)

Clinical Significance of Plasma CD9-Positive Exosomes in HIV Seronegative and Seropositive Lung Cancer Patients
por: Dimitrakopoulos, Foteinos-Ioannis, et al.
Publicado: (2021)

Myo1e overexpression in lung adenocarcinoma is associated with increased risk of mortality
por: Jusue-Torres, Ignacio, et al.
Publicado: (2023)

Molecular findings reveal possible resistance mechanisms in a patient with ALK-rearranged lung cancer: a case report and literature review
por: Kougioumtzi, Anastasia, et al.
Publicado: (2019)

Phase 2 study of cabazitaxel as second-line treatment in patients with HER2-negative metastatic breast cancer previously treated with taxanes—a Hellenic Cooperative Oncology Group (HeCOG) Trial
por: Koutras, Angelos, et al.
Publicado: (2020)

Cost-effectiveness of trifluridine/tipiracil against nivolumab for heavily pretreated metastatic gastric cancer in Japan
por: Takushima, Yusuke, et al.
Publicado: (2021)

Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness
por: Sirinian, Chaido, et al.
Publicado: (2022)

Nivolumab in Heavily Pretreated Metastatic Gastric Cancer Patients: Real-Life Data from a Western Population
por: Petrillo, Angelica, et al.
Publicado: (2020)

Epidermal growth factor receptor status and Notch inhibition in non-small cell lung cancer cells
por: Giannopoulou, Efstathia, et al.
Publicado: (2015)

Differential Expression of the Insulin-Like Growth Factor Receptor among Early Breast Cancer Subtypes
por: Mountzios, Giannis, et al.
Publicado: (2014)

Report of a germline double heterozygote in MSH2 and PALB2
por: Agiannitopoulos, Konstantinos, et al.
Publicado: (2020)

Improvement of Chemotherapy Solutions Production Procedure in a Hospital Central Chemotherapy Preparation Unit: A Systematic Risk Assessment to Prevent Avoidable Harm in Cancer Patients
por: Bourika, Klio, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_86648nq16ubpipba6ccepevsmp