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Left hemisphere abnormalities in developmental prosopagnosia when looking at faces but not words
Developmental prosopagnosia is a disorder characterized by profound and lifelong difficulties with face recognition in the absence of sensory or intellectual deficits or known brain injury. While there has been a surge in research on developmental prosopagnosia over the last decade and a half, the c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425287/ https://www.ncbi.nlm.nih.gov/pubmed/32954273 http://dx.doi.org/10.1093/braincomms/fcz034 |
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author | Gerlach, Christian Klargaard, Solja K Alnæs, Dag Kolskår, Knut K Karstoft, Jens Westlye, Lars T Starrfelt, Randi |
author_facet | Gerlach, Christian Klargaard, Solja K Alnæs, Dag Kolskår, Knut K Karstoft, Jens Westlye, Lars T Starrfelt, Randi |
author_sort | Gerlach, Christian |
collection | PubMed |
description | Developmental prosopagnosia is a disorder characterized by profound and lifelong difficulties with face recognition in the absence of sensory or intellectual deficits or known brain injury. While there has been a surge in research on developmental prosopagnosia over the last decade and a half, the cognitive mechanisms behind the disorder and its neural underpinnings remain elusive. Most recently it has been proposed that developmental prosopagnosia may be a manifestation of widespread disturbance in neural migration which affects both face responsive brain regions as well as other category-sensitive visual areas. We present a combined behavioural and functional MRI study of face, object and word processing in a group of developmental prosopagnosics (N = 15). We show that developmental prosopagnosia is associated with reduced activation of core ventral face areas during perception of faces. The reductions were bilateral but tended to be more pronounced in the left hemisphere. As the first study to address category selectivity for word processing in developmental prosopagnosia, we do not, however, find evidence for reduced activation of the visual word form area during perception of orthographic material. We also find no evidence for reduced activation of the lateral occipital complex during perception of objects. These imaging findings correspond well with the behavioural performance of the developmental prosopagnosics, who show severe impairment for faces but normal reading and recognition of line drawings. Our findings suggest that a general deficit in neural migration across ventral occipito-temporal cortex is not a viable explanation for developmental prosopagnosia. The finding of left hemisphere involvement in our group of developmental prosopagnosics was at first surprising. However, a closer look at existing studies shows similar, but hitherto undiscussed, findings. These left hemisphere abnormalities seen in developmental prosopagnosia contrasts with lesion and imaging studies suggesting primarily right hemisphere involvement in acquired prosopagnosia, and this may reflect that the left hemisphere is important for the development of a normal face recognition network. |
format | Online Article Text |
id | pubmed-7425287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74252872020-09-17 Left hemisphere abnormalities in developmental prosopagnosia when looking at faces but not words Gerlach, Christian Klargaard, Solja K Alnæs, Dag Kolskår, Knut K Karstoft, Jens Westlye, Lars T Starrfelt, Randi Brain Commun Original Article Developmental prosopagnosia is a disorder characterized by profound and lifelong difficulties with face recognition in the absence of sensory or intellectual deficits or known brain injury. While there has been a surge in research on developmental prosopagnosia over the last decade and a half, the cognitive mechanisms behind the disorder and its neural underpinnings remain elusive. Most recently it has been proposed that developmental prosopagnosia may be a manifestation of widespread disturbance in neural migration which affects both face responsive brain regions as well as other category-sensitive visual areas. We present a combined behavioural and functional MRI study of face, object and word processing in a group of developmental prosopagnosics (N = 15). We show that developmental prosopagnosia is associated with reduced activation of core ventral face areas during perception of faces. The reductions were bilateral but tended to be more pronounced in the left hemisphere. As the first study to address category selectivity for word processing in developmental prosopagnosia, we do not, however, find evidence for reduced activation of the visual word form area during perception of orthographic material. We also find no evidence for reduced activation of the lateral occipital complex during perception of objects. These imaging findings correspond well with the behavioural performance of the developmental prosopagnosics, who show severe impairment for faces but normal reading and recognition of line drawings. Our findings suggest that a general deficit in neural migration across ventral occipito-temporal cortex is not a viable explanation for developmental prosopagnosia. The finding of left hemisphere involvement in our group of developmental prosopagnosics was at first surprising. However, a closer look at existing studies shows similar, but hitherto undiscussed, findings. These left hemisphere abnormalities seen in developmental prosopagnosia contrasts with lesion and imaging studies suggesting primarily right hemisphere involvement in acquired prosopagnosia, and this may reflect that the left hemisphere is important for the development of a normal face recognition network. Oxford University Press 2019-12-20 /pmc/articles/PMC7425287/ /pubmed/32954273 http://dx.doi.org/10.1093/braincomms/fcz034 Text en © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Article Gerlach, Christian Klargaard, Solja K Alnæs, Dag Kolskår, Knut K Karstoft, Jens Westlye, Lars T Starrfelt, Randi Left hemisphere abnormalities in developmental prosopagnosia when looking at faces but not words |
title | Left hemisphere abnormalities in developmental prosopagnosia when looking at faces but not words |
title_full | Left hemisphere abnormalities in developmental prosopagnosia when looking at faces but not words |
title_fullStr | Left hemisphere abnormalities in developmental prosopagnosia when looking at faces but not words |
title_full_unstemmed | Left hemisphere abnormalities in developmental prosopagnosia when looking at faces but not words |
title_short | Left hemisphere abnormalities in developmental prosopagnosia when looking at faces but not words |
title_sort | left hemisphere abnormalities in developmental prosopagnosia when looking at faces but not words |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425287/ https://www.ncbi.nlm.nih.gov/pubmed/32954273 http://dx.doi.org/10.1093/braincomms/fcz034 |
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