Cargando…

Using Mendelian randomization to understand and develop treatments for neurodegenerative disease

Common neurodegenerative diseases are thought to arise from a combination of environmental and genetic exposures. Mendelian randomization is a powerful way to leverage existing genetic data to investigate causal relationships between risk factors and disease. In recent years, Mendelian randomization...

Descripción completa

Detalles Bibliográficos
Autores principales:	Storm, Catherine S, Kia, Demis A, Almramhi, Mona, Wood, Nicholas W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425289/ https://www.ncbi.nlm.nih.gov/pubmed/32954289 http://dx.doi.org/10.1093/braincomms/fcaa031

Ejemplares similares

Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome
por: Storm, Catherine S., et al.
Publicado: (2021)

Exploring the Role of Plasma Lipids and Statin Interventions on Multiple Sclerosis Risk and Severity: A Mendelian Randomization Study
por: Almramhi, Mona M., et al.
Publicado: (2023)

Mendelian Randomization Study Shows No Causal Relationship Between Circulating Urate Levels and Parkinson’s Disease
por: Kia, Demis A., et al.
Publicado: (2018)

The Parkinson's Disease Mendelian Randomization Research Portal
por: Noyce, Alastair J., et al.
Publicado: (2019)

Neurodegenerative disease and antioxidant biomarkers: A bidirectional Mendelian randomization study
por: Zhang, Qianqian, et al.
Publicado: (2023)

Mendelian neurodegenerative disease genes involved in autophagy
por: Stamatakou, Eleanna, et al.
Publicado: (2020)

A Mendelian Randomization Study of Plasma Homocysteine Levels and Cerebrovascular and Neurodegenerative Diseases
por: Liu, Weishi, et al.
Publicado: (2021)

Genetic predisposition to neurodegenerative diseases and risk of stroke: A Mendelian randomization study
por: Li, Fuju, et al.
Publicado: (2022)

Effects of ulcerative colitis and Crohn’s disease on neurodegenerative diseases: A Mendelian randomization study
por: Li, Hong, et al.
Publicado: (2022)

Assessment of causal effects of physical activity on neurodegenerative diseases: A Mendelian randomization study
por: Wu, Peng-Fei, et al.
Publicado: (2021)

Physical activities and risk of neurodegenerative diseases: A two-sample Mendelian randomization study
por: Liao, Qiao, et al.
Publicado: (2022)

Systematic Screening of Associations between Medication Use and Risk of Neurodegenerative Diseases Using a Mendelian Randomization Approach
por: Wang, Wenjing, et al.
Publicado: (2023)

COVID-19 and risk of neurodegenerative disorders: A Mendelian randomization study
por: Li, Chunyu, et al.
Publicado: (2022)

The Role of PERK in Understanding Development of Neurodegenerative Diseases
por: Smedley, Garrett Dalton, et al.
Publicado: (2021)

Use of Mendelian randomization to better understand and treat sepsis
por: Russell, James A., et al.
Publicado: (2022)

Associations of cardiovascular risk factors and lifestyle behaviors with neurodegenerative disease: a Mendelian randomization study
por: Huang, Liang-Yu, et al.
Publicado: (2023)

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease
por: Fernández, Maria Victoria, et al.
Publicado: (2017)

Author Correction: Mendelian neurodegenerative disease genes involved in autophagy
por: Stamatakou, Eleanna, et al.
Publicado: (2020)

Mendelian Randomization — the Key to Understanding Aspects of Parkinson's Disease Causation?
por: Noyce, Alastair J., et al.
Publicado: (2015)

Mendelian randomization: Progressing towards understanding causality
por: König, Inke R., et al.
Publicado: (2018)

Are neurodegenerative diseases associated with an increased risk of inflammatory bowel disease? A two-sample Mendelian randomization study
por: Cui, Guanghui, et al.
Publicado: (2022)

Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study
por: Noyce, Alastair J., et al.
Publicado: (2017)

Genetic Liability to Sedentary Behavior in Relation to Stroke, Its Subtypes and Neurodegenerative Diseases: A Mendelian Randomization Study
por: Yang, Fangkun, et al.
Publicado: (2021)

Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead
por: Lake, Julie, et al.
Publicado: (2021)

Stratification of candidate genes for Parkinson’s disease using weighted protein-protein interaction network analysis
por: Ferrari, Raffaele, et al.
Publicado: (2018)

Transcranial magnetic stimulation to understand pathophysiology and as potential treatment for neurodegenerative diseases
por: Ni, Zhen, et al.
Publicado: (2015)

Guide to Understanding Drosophila Models of Neurodegenerative Diseases
por: Jackson, George R
Publicado: (2008)

Using multiple Mendelian randomization approaches and genetic correlations to understand obesity, urate, and gout
por: Adams, Charleen D., et al.
Publicado: (2021)

Recent Developments in Mendelian Randomization Studies
por: Zheng, Jie, et al.
Publicado: (2017)

A Guide for Understanding and Designing Mendelian Randomization Studies in the Musculoskeletal Field
por: Hartley, April E, et al.
Publicado: (2022)

Understanding Miro GTPases: Implications in the Treatment of Neurodegenerative Disorders
por: Kay, Laura, et al.
Publicado: (2018)

Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization
por: Ong, Jue-Sheng, et al.
Publicado: (2018)

Mendelian randomization in family data
por: Morris, Nathan J, et al.
Publicado: (2009)

Understanding the effect of smoking and drinking behavior on Parkinson's disease risk: a Mendelian randomization study
por: Domínguez-Baleón, Carmen, et al.
Publicado: (2021)

Genetically predicted circulating levels of glycine, glutamate, and serotonin in relation to the risks of three major neurodegenerative diseases: A Mendelian randomization analysis
por: Li, Ruizhuo, et al.
Publicado: (2022)

Assessing causal relationship between circulating cytokines and age-related neurodegenerative diseases: a bidirectional two-sample Mendelian randomization analysis
por: Yin, Zihan, et al.
Publicado: (2023)

Using Mendelian Randomization to Decipher Mechanisms of Bone Disease
por: Trajanoska, Katerina, et al.
Publicado: (2018)

Using genetics to understand the role of kidney function in COVID-19: a mendelian randomization study
por: Zhao, Jie V., et al.
Publicado: (2021)

MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data
por: Yavorska, Olena O, et al.
Publicado: (2017)

Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence
por: Kolodkin, Alexey, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_sp2eas62jd6c7avm8t9i5jgu1p