Attenuating the DNA damage response to double-strand breaks restores function in models of CNS neurodegeneration

DNA double-strand breaks are a feature of many acute and long-term neurological disorders, including neurodegeneration, following neurotrauma and after stroke. Persistent activation of the DNA damage response in response to double-strand breaks contributes to neural dysfunction and pathology as it c...

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Detalles Bibliográficos
Autores principales: Tuxworth, Richard I, Taylor, Matthew J, Martin Anduaga, Ane, Hussien-Ali, Alaa, Chatzimatthaiou, Sotiroula, Longland, Joanne, Thompson, Adam M, Almutiri, Sharif, Alifragis, Pavlos, Kyriacou, Charalambos P, Kysela, Boris, Ahmed, Zubair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425387/
https://www.ncbi.nlm.nih.gov/pubmed/32954257
http://dx.doi.org/10.1093/braincomms/fcz005

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