Phenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency

Mutations in ATP13A2 (PARK9) are causally linked to the rare neurodegenerative disorders Kufor-Rakeb syndrome, hereditary spastic paraplegia and neuronal ceroid lipofuscinosis. This suggests that ATP13A2, a lysosomal cation-transporting ATPase, plays a crucial role in neuronal cells. The heterogenei...

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Detalles Bibliográficos
Autores principales: Heins-Marroquin, Ursula, Jung, Paul P, Cordero-Maldonado, Maria Lorena, Crawford, Alexander D, Linster, Carole L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425419/
https://www.ncbi.nlm.nih.gov/pubmed/32954262
http://dx.doi.org/10.1093/braincomms/fcz019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425419/
https://www.ncbi.nlm.nih.gov/pubmed/32954262
http://dx.doi.org/10.1093/braincomms/fcz019

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