LKB1 inactivation leads to centromere defects and genome instability via p53-dependent upregulation of survivin

Inactivating mutations in the liver kinase B1 (LKB1) tumor suppressor gene underlie Peutz-Jeghers syndrome (PJS) and occur frequently in various human cancers. We previously showed that LKB1 regulates centrosome duplication via PLK1. Here, we report that LKB1 further helps to maintain genomic stabil...

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Detalles Bibliográficos
Autores principales: Jin, Li-Yan, Zhao, Kui, Xu, Long-Jiang, Zhao, Rui-Xun, Werle, Kaitlin D., Wang, Yong, Liu, Xiao-Long, Chen, Qiu, Wu, Zhuo-Jun, Zhang, Ke, Zhao, Ying, Jiang, Guo-Qin, Cui, Feng-Mei, Xu, Zhi-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425461/
https://www.ncbi.nlm.nih.gov/pubmed/32668413
http://dx.doi.org/10.18632/aging.103473

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