Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome?

Mesenchymal stromal cells (MSC) have immune regulatory and tissue regenerative properties. MSCs are being studied as a therapy option for many inflammatory and immune disorders and are approved to treat acute graft-versus-host disease (GvHD). The severe acute respiratory syndrome coronavirus-2 (SARS...

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Autores principales: Hamdan, Hamdan, Hashmi, Shahrukh K., Lazarus, Hillard, Gale, Robert Peter, Qu, Wenchun, El Fakih, Riad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425550/
https://www.ncbi.nlm.nih.gov/pubmed/32854985
http://dx.doi.org/10.1016/j.blre.2020.100742
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author Hamdan, Hamdan
Hashmi, Shahrukh K.
Lazarus, Hillard
Gale, Robert Peter
Qu, Wenchun
El Fakih, Riad
author_facet Hamdan, Hamdan
Hashmi, Shahrukh K.
Lazarus, Hillard
Gale, Robert Peter
Qu, Wenchun
El Fakih, Riad
author_sort Hamdan, Hamdan
collection PubMed
description Mesenchymal stromal cells (MSC) have immune regulatory and tissue regenerative properties. MSCs are being studied as a therapy option for many inflammatory and immune disorders and are approved to treat acute graft-versus-host disease (GvHD). The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic and associated coronavirus infectious disease-19 (COVID-19) has claimed many lives. Innovative therapies are needed. Preliminary data using MSCs in the setting of acute respiratory distress syndrome (ARDS) in COVID-19 are emerging. We review mechanisms of action of MSCs in inflammatory and immune conditions and discuss a potential role in persons with COVID-19.
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spelling pubmed-74255502020-08-14 Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome? Hamdan, Hamdan Hashmi, Shahrukh K. Lazarus, Hillard Gale, Robert Peter Qu, Wenchun El Fakih, Riad Blood Rev Review Mesenchymal stromal cells (MSC) have immune regulatory and tissue regenerative properties. MSCs are being studied as a therapy option for many inflammatory and immune disorders and are approved to treat acute graft-versus-host disease (GvHD). The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic and associated coronavirus infectious disease-19 (COVID-19) has claimed many lives. Innovative therapies are needed. Preliminary data using MSCs in the setting of acute respiratory distress syndrome (ARDS) in COVID-19 are emerging. We review mechanisms of action of MSCs in inflammatory and immune conditions and discuss a potential role in persons with COVID-19. Elsevier Ltd. 2021-03 2020-08-13 /pmc/articles/PMC7425550/ /pubmed/32854985 http://dx.doi.org/10.1016/j.blre.2020.100742 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Hamdan, Hamdan
Hashmi, Shahrukh K.
Lazarus, Hillard
Gale, Robert Peter
Qu, Wenchun
El Fakih, Riad
Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome?
title Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome?
title_full Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome?
title_fullStr Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome?
title_full_unstemmed Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome?
title_short Promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (COVID-19)-related severe acute respiratory syndrome?
title_sort promising role for mesenchymal stromal cells in coronavirus infectious disease-19 (covid-19)-related severe acute respiratory syndrome?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425550/
https://www.ncbi.nlm.nih.gov/pubmed/32854985
http://dx.doi.org/10.1016/j.blre.2020.100742
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